Farnesoid X Receptor Activation by Obeticholic Acid Elevates Liver Low-Density Lipoprotein Receptor Expression by mRNA Stabilization and Reduces Plasma Low-Density Lipoprotein Cholesterol in Mice.

Conclusions- Our study is the first to demonstrate that FXR activation increases LDLR expression in liver tissue by a post-transcriptional regulatory mechanism involving LDLR mRNA-stabilizing factor HuR. PMID: 30354208 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30354208?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 1, 2018 Category: Cardiology Authors: Singh AB, Dong B, Kraemer FB, Xu Y, Zhang Y, Liu J Tags: Arterioscler Thromb Vasc Biol Source Type: research