Lack of association between sirtuin gene variants and endometrial cancer

This study took paraffin-embedded endometrium specimens from 48 endometrial cancer patients and 53 healthy control subjects. SIRT1 gene variants were determined with the PCR-CCTP method. The result of the single-nucleotide polymorphism (SNP) analysis indicated no significant relationship with endometrial cancer. Recent studies have shown that SIRT has had a positive effect on endometrial tumors. Our study analyzed, for the first time, the association between SIRT1 gene polymorphisms and endometrial cancer. Because of the low population our results are not reflecting the exact contribution of the polymorphism to the development of the disease, further studies need to be performed with higher population numbers. Therefore, further studies on a larger population in cohort studies will be required to confirm whether polymorphism is a potential novel genetic marker.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research