Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model

In this study, we used the Ts65Dn mouse model of DS to evaluate the beneficial effect of a DNA vaccination against the Aβ1-11 fragment, in ameliorating Aβ-related neuropathology and rescue of cognitive and behavioral abilities. Anti-Aβ1-11 vaccination induced antibody production and facilitated clearance of soluble oligomers and small extracellular inclusions of Aβ from the hippocampus and cortex of Ts65Dn mice. This was correlated with reduced neurodegeneration and restoration of the homeostatic phenotype of microglial and astroglial cells. Vaccinated Ts65Dn mice performed better in spatial-learning tasks, exhibited reduced motor hyperactivity typical for this strain, and restored short-term memory abilities.Our findings support the hypothesis that DS individuals may benefit from active immunotherapy against Aβ from a young age by slowing the progression of dementia.
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research

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Publication date: Available online 17 September 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Mihaela Bustuchina VlaicuAbstractThis is a review paper, essentially a commentary with summary of literature that actualizes the problem of epilepsy in patients with multiple sclerosis. There is a bidirectional relation between multiple sclerosis and epilepsy. A possible associate pathophysiological pathway is considered. In multiple sclerosis, a combination of grey matter involvement and inflammation could influence epileptogenesis. Patients with multiple sclerosis have individual profiles and an inter-individual...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Download this application note to learn how the ACEA xCELLigence system can evaluate the potency of an immunotherapy against a broad spectrum of liquid tumors and monitor the destruction kinetics of...
Source: The Scientist - Category: Science Tags: The Marketplace Source Type: news
AbstractBackgroundThe neutrophil to lymphocyte ratio (NLR) is known to be prognostic for patients with advanced cancers treated with immune checkpoint inhibitors (ICI), but has generally been evaluated as a single threshold value at baseline. We evaluated NLR at baseline and within first month during treatment in patients who received ICI for advanced cancer to evaluate the prognostic value of baseline and of changes from baseline to on-treatment NLR.MethodsA retrospective review of patients with advanced cancer treated with ICI from 2011 to 2017 at the Ohio State University was performed. NLR was calculated at the initiat...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionThe trial demonstrated a favorable safety profile of the SQ HDM SLIT-tablet in Japanese adult patients with AA. The treatment appeared to be efficacious in patients requiring rescue medication (i.e., SABA) at baseline in the efficacy assessment using asthma exacerbation during ICS reduction (JapicCTI number 121847).
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
A selective peroxisome proliferator-activated receptor-γ agonist benefited propionic acid induced autism-like behavioral phenotypes in rats by attenuation of neuroinflammation and oxidative stress. Chem Biol Interact. 2019 Sep 25;311:108758 Authors: Mirza R, Sharma B Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder in children. It is diagnosed by two main behavioral phenotypes i.e. social-communication impairments and repetitive behavior. ASD is complex disorder with unsolved etiology due to multiple genes involvement, epigenetic mechanism and environmental factors. The c...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
FLU vaccine ’s are available each year in the UK from late September to early October. Why are they so important and which pharmacies offer them for free?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
WEDNESDAY, Sept. 18, 2019 -- Anemia diagnosed during the first 30 weeks of pregnancy is associated with an increased risk for autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and intellectual disability (ID),...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Researchers from the HIV Vaccine Trials Network in Seattle, Washington, gave a HIV vaccine to 100 people in South Africa and found their bodies developed white blood cells for fighting the virus.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Caring for someone with Alzheimer's disease can be both challenging and rewarding. Learn about tips to make it easier, as well as when to seek professional help.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
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