Ephrin-A2 affects wound healing and scarring in a murine model of excisional injury

Eph receptor/Ephrin ligand interactions are important in neuronal mapping and topography in central and peripheral nerves [1]. All the Eph receptors and Ephrin ligands are expressed in normal human skin [2] and Ephrin-A ligand signaling has been shown to be important in hair follicle cycling and epidermal differentiation [3 –5]. Ephrin A2 and A5 are critical for sensory axonal growth patterning and in the development of cutaneous innervation in animal models [4–7]. In addition, keratinocytes treated with human Fc-conjugated Ephrin-A ligands have been shown to suppress the expression of important cell adhesion genes such as integrin β6 and integrin β4, suggesting Ephrin signaling may influence cell migration through reduced cell attachment and increased motility [4].

Source: Burns : Journal of the International Society for Burn Injuries - October 25, 2018 Category: Cosmetic Surgery Authors: Dulharie Wijeratne, Jennifer Rodger, Andrew Stevenson, Hilary Wallace, Cecilia M. Pr êle, Fiona M. Wood, Mark W. Fear Source Type: research