Sodium butyrate inhibits the production of HMGB1 and attenuates severe burn plus delayed resuscitation-induced intestine injury via the p38 signaling pathway

Prompt and adequate resuscitation has been documented to play a vital role in the outcome of severely burned patients [1]. However, in the rural areas, especially in the developing countries, the fluid resuscitation is frequently delayed due to the referral transportation and lack of burn knowledge. Inadequate or delayed fluid resuscitation leads to tissue hypoperfusion, which can result in early organ injury and failure [2]. Rapid infusion to replace loss of fluid within 2h is effective to maintain vital organ function and prevent progressive organ damage [3].

Source: Burns : Journal of the International Society for Burn Injuries - October 25, 2018 Category: Cosmetic Surgery Authors: Sheng Liu, Hong-Ze Chen, Zheng-Dong Xu, Fei Wang, Haoshu Fang, Ophelia Bellanfante, Xu-Lin Chen Source Type: research