Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits

Characterizing the complex relationship between genetic, epigenetic, and transcriptomic variation has the potential to increase understanding about the mechanisms underpinning health and disease phenotypes. We undertook a comprehensive analysis of common genetic variation on DNA methylation (DNAm) by using the Illumina EPIC array to profile samples from the UK Household Longitudinal study. We identified 12,689,548 significant DNA methylation quantitative trait loci (mQTL) associations (p

Source: The American Journal of Human Genetics - October 25, 2018 Category: Genetics & Stem Cells Authors: Eilis Hannon, Tyler J. Gorrie-Stone, Melissa C. Smart, Joe Burrage, Amanda Hughes, Yanchun Bao, Meena Kumari, Leonard C. Schalkwyk, Jonathan Mill Tags: Article Source Type: research