FUT2 Variants Confer Susceptibility to Familial Otitis Media

Non-secretor status due to homozygosity for the common FUT2 variant c.461G>A (p.Trp154 ∗) is associated with either risk for autoimmune diseases or protection against viral diarrhea and HIV. We determined the role of FUT2 in otitis media susceptibility by obtaining DNA samples from 609 multi-ethnic families and simplex case subjects with otitis media. Exome and Sanger sequencing, li nkage analysis, and Fisher exact and transmission disequilibrium tests (TDT) were performed. The common FUT2 c.604C>T (p.Arg202 ∗) variant co-segregates with otitis media in a Filipino pedigree (LOD = 4.0).

Source: The American Journal of Human Genetics - October 25, 2018 Category: Genetics & Stem Cells Authors: Regie Lyn P. Santos-Cortez, Charlotte M. Chiong, Daniel N. Frank, Allen F. Ryan, Arnaud P.J. Giese, Tori Bootpetch Roberts, Kathleen A. Daly, Matthew J. Steritz, Wasyl Szeremeta, Melquiadesa Pedro, Harold Pine, Talitha Karisse L. Yarza, Melissa A. Scholes Tags: Article Source Type: research