Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

THURSDAY, Oct. 25, 2018 -- For patients with gout, allopurinol is associated with a reduced risk for developing chronic kidney disease stage ≥3, according to a study published online Oct. 8 in JAMA Internal Medicine. Ana Beatriz Vargas-Santos,...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news

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What are the dos and don'ts when treating gout patients with chronic kidney disease? Take our 4-question quiz to find out.
Source: ConsultantLive - Category: Internal Medicine Authors: Source Type: news
Abstract The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on. Serum uric acid levels are maintained by the balance between production and elimination. There are many factors that maintain the balance of serum uric acid. One of them is transporters which are responsible for the debouchment of uric acid within blood. The transport and excretion of uric acid is a complicated procedure which is related with various transporters such as OAT1, OAT3, OAT4, URAT1, GLUT9, BCRP, MRP4, NPT1, NTP4, and so on...
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
An association between gout and renal disease is well-recognised but few studies have examined whether gout is a risk factor for subsequent chronic kidney disease (CKD). Additionally, the impact of urate-lower...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
NEW YORK (Reuters Health)—Allopurinol does not appear to contribute to decline in kidney function and may actually protect renal function in patients with gout, according to a large population-based study. Gout affects around 4% of Americans and often occurs alongside chronic kidney disease (CKD), Dr. Tuhina Neogi from Boston University School of Medicine and colleagues... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Crystal Arthritis Allopurinol chronic kidney disease Gout Source Type: research
Allopurinol, used to manage gout, was not associated with renal function decline and may protect against development of chronic kidney disease.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Source Type: news
This cohort study uses data from the UK Health Improvement Network to examine the association of allopurinol use in patients with gout with the risk of developing chronic kidney disease stage 3 or higher.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
AbstractTo retrospectively analyze the efficacy and safety of febuxostat on gout patients with low serum uric acid level. A study was conducted in Nanjing First Hospital from October 2015 to September 2016. Thirty nine acute gouty arthritis patients from the emergency and outpatient department were included. Patients met the 2015 Gout Classification Criteria revised by American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) and had urate deposition around the joints detected by dual-energy computerized tomography (DECT). Patients whose serum uric acid (SUA) were between 5.0 and 7.0  mg/dl (300&...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
CONCLUSIONS: ACTH is a fast acting, efficacious and well-tolerated option for patients with acute gout when traditional therapies have failed or are contraindicated. However, large, carefully designed, randomised controlled trials are required to confirm these findings. PMID: 30183601 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Fülöp T, Koch CA, Norris LT, Rodríguez B, Szarvas T, Lengvárszky Z, Csongrádi É, Dixit MP Abstract OBJECTIVES: Uric acid (UA) control may be insufficient in chronic kidney disease (CKD) patients in the current era. It is unclear, however, whether this is the result of environmental effects, patient anthropometrics or insufficient dosing of medical therapy (allopurinol). METHODS: We have collected data on multiple clinical and laboratory parameters of 114 CKD clinic patients attending the nephrology clinic of the University of Mississippi Medical Center with an esti...
Source: Southern Medical Journal - Category: General Medicine Tags: South Med J Source Type: research
ConclusionsThe higher risk for ESRD in recurrent symptomatic compared with incident symptomatic kidney stone formers suggests that stone events are associated with kidney injury. The clinical indication for imaging in asymptomatic stone formers, the correct diagnosis in miscoded stone formers, and the cause of a bladder outlet obstruction in bladder stone formers may explain the higher risk for ESRD or death in these groups.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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