Distribution of HAP1-immunoreactive cells in the retrosplenial–retrohippocampal area of adult rat brain and its application to a refined neuroanatomical understanding of the region

Publication date: Available online 24 October 2018Source: NeuroscienceAuthor(s): Greggory Wroblewski, Md. Nabiul Islam, Akie Yanai, Mir Rubayet Jahan, Koh-hei Masumoto, Koh ShinodaAbstractHuntingtin-associated protein 1 (HAP1) is a neural interactor of huntingtin in Huntington’s disease, and interacts with gene products in a number of other neurodegenerative diseases. In normal brains, HAP1 is expressed abundantly in the hypothalamus and limbic-associated regions. These areas tend to be spared from neurodegeneration while those with little HAP1 are frequently neurodegenerative targets, suggesting its role as a protective factor against apoptosis. In light of the relationship between neurodegenerative diseases and deterioration of higher nervous activity, it is important to definitively clarify HAP1 expression in a cognitively important brain region, the retrosplenial–retrohippocampal area. Here, HAP1 expression was evaluated immunohistochemically over the retrosplenial cortex, the subicular complex, and the entorhinal and perirhinal cortices. HAP1-immunoreactive (ir) cells were classified into five discrete groups: (1) a distinct retrosoplenial cell cluster exclusive to the superficial layers of the granular cortex, (2) a conspicuous, thin line of cells in layers IV/V of the “subiculum-backing cortex,” (3) a group of highly immunoreactive cells associated with the medial entorhinal–subicular corner, (4) pericallosal cells just below layer VI and adjacent to the whit...
Source: Neuroscience - Category: Neuroscience Source Type: research
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