Altered hematological, biochemical and immunological parameters as predictive biomarkers of severity in experimental myocardial infarction

Publication date: Available online 24 October 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Rebeca Blázquez, Verónica Álvarez, Juan Antonio Antequera-Barroso, Claudia báez-Díaz, Virginia Blanco, Juan Maestre, Beatriz Moreno-Lobato, Esther López, Federica Marinaro, Javier G Casado, Verónica Crisóstomo, Francisco Miguel Sánchez-MargalloAbstractPreclinical studies in cardiovascular medicine are necessary to translate basic research to the clinic. The porcine model has been widely used to understand the biological mechanisms involved in cardiovascular disorders for which purpose different closed-chest models have been developed in the last years to mimic the pathophysiological events seen in human myocardial infarction.In this work, we studied hematological, biochemical and immunological parameters, as well as Magnetic resonance derived cardiac function measurements obtained from a swine myocardial infarction model. We identified some blood parameters which were significantly altered after myocardial infarction induction. More importantly, these parameters (gamma-glutamyl transferase, glutamic pyruvic transaminase, red blood cell counts, hemoglobin concentration, hematocrit, platelet count and plateletcrit) correlated positively with cardiac function, infarct size and/or cardiac enzymes (troponin I and creatine kinase-MB).Thus several blood-derived parameters have allowed us to predict the severity of myocardial infarction in a clinically relevant anima...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research