Chronic itch impairs mood and HPA axis function in mice: modulation by CRFR1 antagonist

Chronic itch is clinically correlated with the development of mood disorders such as anxiety and depression. Nonetheless, whether this relevance exists in rodents is unknown, and evidence demonstrating chronic itch can affect mood is lacking. The aim of this study is to characterize the affective consequences of chronic itch, and explore potential mechanisms and interventional strategy. We subjected mice to chronic itch by repetitive cutaneous treatment with acetone and diethylether followed by water (AEW) that models “dry skin.” After 3 to 4 weeks AEW treatment, the mice developed behavioral phenotypes of anxiety and depression assessed by a battery of behavioral paradigms, such as light–dark box and forced swim test. These behavioral symptoms of mood disturbance were independent of cutaneous barrier disruption, but correlated well with the degree of the irritating itch sensation. Although AEW mice showed normal circadian hypothalamic-pituitary-adrenal (HPA) axis activity, their neuroendocrine functionality was dampened, including impaired endocrine stress responsivity, altered neuroendocrine–immune interaction, and blunted corticosterone response to both dexamethasone and CRF. Parameters of HPA functionality at the level of mRNA transcripts are altered in stress-related brain regions of AEW mice, implying an overdrive of central CRF system. Remarkably, chronic treatment of AEW mice with antalarmin, a CRFR1 antagonist, ameliorated both their mood impa...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

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Authors: Van Slambrouck J, Vlasselaers J, Devos B Abstract Peritoneal tuberculosis is a rare extrapulmonary manifestation of tuberculosis. Considering the diagnosis of peritoneal tuberculosis in a low prevalence setting can be vital for the further clinical management in selected patients.In a young male with migration background, presenting with generalised abdominal pain, computed tomography revealed ascites, omental and peritoneal thickening and enlarged mesentery lymph nodes. Computed tomography also revealed a distal ureteral calculus at the right vesico-ureteral junction. Diagnostic laparoscopy showed a nodul...
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
Publication date: Available online 18 November 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Z Malihi, Z Wu, CMM Lawes, J Sluyter, D Waayer, L Toop, K-T Khaw, CA Camargo, R ScraggABSTRACTWith increasing numbers of randomized controlled trials (RCTs) investigating potential health events of vitamin D supplementation, a better understanding is required of the risk factors for adverse events and for study withdrawals. This analysis aimed to identify baseline risk factors of reporting an adverse event in a multi-year randomized double-blinded placebo-controlled trial of vitamin D supplementati...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Conclusion and Future Directions G protein bias may either be affinity/potency-dominant or efficacy-dominant (Table 1). A potential concern is that, despite using the same cellular assays, variations in agonist potency were determined by different, or even the same labs, potentially due to differences in expression levels of the receptor and signaling proteins that occurred during cell passaging. For example the reported arrestin recruitment potency for U69,593 has been reported to be as low as 67.7 nM (Spetea et al., 2017) and as high as 410 nM (Dunn et al., 2018), similarly for U50,488 potency has ranged from 36 to 1000...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Parnell LKS Abstract Chronic itch continues to be a problem that plagues millions of humans and animals. Pruritus has a negative impact on patient quality of life and many patients experience sleep deprivation, anxiety, and depression, similar to patients with chronic pain. This review provides an overview of clinical pruritus research with special emphasis on itch that wound care providers may see. In addition, the need for using multifactorial questionnaires for better research in pruritus is summarized. Similarities and differences in itch characteristics, triggers, and relievers in various patient popu...
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
This article reviews the acute neural transmission of pain, pruritus, and nausea symptoms, which can begin in the periphery and/or viscera. The subsequent multiple pathways in the central nervous system that become involved in the processing of these symptoms are also discussed. The authors describe human brain imaging studies that have revealed consistent cortical and subcortical networks  activated by these symptoms, including sensory, limbic, and associative regions. In particular, the authors discuss information revealed by the studies regarding the primary somatosensory cortex, secondary somatosensory cortex, ant...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Neurologic Systems and Symptoms Neurology Pain Review central processing nausea pruritus Source Type: research
Discussion Fatigue is a subjective feeling of decreased energy, tiredness or feeling of exhaustion. Lethargy is often used synonymously, but lethargy is a state of being drowsiness or sleepy, and implies mental status changes. Both can cause the person to be apathetic or less active. Fatigue is a common state that almost everyone experiences multiple times in his or her lifetime. For most people it is a relatively acute or short-term chronic problem, often with a relatively easily identifiable problem cause, such as inadequate sleep, acute illness, or overexertion. For some, it can be less readily identifiable such as dep...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Conclusion Doctors often assure parents that vaccines are safe, using phrases like “one in a million” and “rare” to describe adverse reactions. Yet, with sad stories like RD’s, thousands of adverse events reported to VAERS, and the creation of a special court for vaccine injuries, informed parents know those vaccine safety claims are simply not true. If you have not already done so, please consider the overall safety of vaccinations. A federal program has awarded billions of dollars, through an arduous, emotionally painful process, to people whose family members have suffered injury or death a...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Case Reports on Vaccine Injury Human Missy Fluegge Patricia Finn transverse myelitis truth about vaccines United States Court of Federal Claims Vaccine Court VAERS Varicella vaccine Source Type: blogs
ConclusionsImpairments in HRQOL are a serious problem in HD patients. CI means an additional burden in affected patients, also impairing their HRQOL. GEHIS showed significant sex differences in HRQOL outcomes also in HD patients. CI and pain as well as sleep frequently occur combined and significantly impair HRQOL in HD patients. The care of HD patients should be complemented by psychosocial support and mental health services.
Source: Quality of Life Research - Category: Health Management Source Type: research
Scarring is considered one of the most devastating consequences of a burn which impacts negatively on quality of life [1 –6]. Scarring has been associated with long term physical limitations including altered sensory function [7], chronic pain [8,9], chronic itch [10–14], and limitations to functional movement [15,16]. The psychosocial sequelae can include social stigmatism [3], social anxiety [17], discrimination [3,18], depression [19,20], post-traumatic stress [3,17] and poor body image [21–23].
Source: Burns : Journal of the International Society for Burn Injuries - Category: Cosmetic Surgery Authors: Source Type: research
When you have eliminated wheat and grains from your life, odd things happen when you get re-exposed. First of all, you’ve lost the partial–partial, never total–tolerance to some of the adverse effects of wheat and grains, and they come back with a vengeance upon re-exposure. And it’s not just due to the “gluten.” Those of you hanging around here understand that there is far more to wheat and grains than gluten, such as reactions to the bowel toxicity of wheat germ agglutinin, or the mind “fog” of gliadin-derived opiate peptides, or allergic reactions to alpha amylase inhibito...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle abdominal pain anxiety bloating Depression diarrhea gluten grains joint pain rash re-exposure seizure vomiting Source Type: blogs
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