Aldehyde dehydrogenase 2 genotype in tolerability of alcohol contained in paclitaxel in Japanese breast cancer patients.

CONCLUSIONS: Our study suggests that PTX up to 100 mg/m2 can be used safely for patients with the ALDH2 GA genotype. To confirm the necessity of a genotyping test for ALDH2, further studies evaluating alcohol sensitivity in response to PTX among patients with the ALDH2 AA genotype are required.
PMID: 30350259 [PubMed - as supplied by publisher]

Source: Breast Cancer - October 22, 2018 Category: Cancer & Oncology Authors: Yagi T, Fujiishi K, Hasegawa A, Otsuka T, Yoshinami T, Nishio M, Fujisawa F, Sugimoto N, Imamura F Tags: Breast Cancer Source Type: research