AGA Issues Guidelines for Opioid-Induced Constipation

WEDNESDAY, Oct. 24, 2018 -- Recommendations for medical management of opioid-induced constipation include laxatives as first-line agents, according to a guideline from the American Gastroenterological Association (AGA) published online Oct. 17 in...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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ConclusionsLaparoscopic mesh rectocolposacropexy and colposacropexy are safe and effective techniques associated with very low morbidity. In the medium term, they provide good results for POP and associated symptoms, but urinary symptomology has a worse outcome.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
Condition:   Constipation - Functional Interventions:   Drug: Lactobacillus plantarum;   Drug: Placebo Sponsors:   Fakultas Kedokteran Universitas Indonesia;   United States Agency for International Development (USAID) Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Clevers et  al1 reported important population-based symptom grouping based on the latest Rome IV questionnaire completed by 5931 participants from the United Kingdom, the United States, and Canada. They found 8 distinct symptom groupings (constipation, diarrhea, irritable bowel syndrome [IBS], abdominal pain, heartburn, nausea/vomiting, globus, and other upper gastrointestinal [GI] symptoms) and reported that these results were consistent with the Rome IV classification for separate upper and lower GI symptoms groups.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Caffeine withdrawal symptoms can occur when a person abruptly stops consuming caffeine. Symptoms can last for a week or more and include headaches, fatigue, mood changes, concentration difficulties, and constipation. Learn more about caffeine withdrawal here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Nutrition / Diet Source Type: news
Approximately 70% SCI patients report chronic pain, with a third characterizing their pain as debilitating. SCI-NP accompanies 40%-60% of SCI cases and is regarded as more severe than nociceptive pain. SCI-NP remains minimally responsive to existing pharmacological and nonpharmacological treatments. Pharmacological agents (e.g., antidepressants, antiepileptics, opioids) provide only a third of patients ’ 50% pain reduction and present significant side effects including constipation, toxification, and addiction.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Erenumab is a calcitonin gene-related peptide (CGRP) monoclonal antibody, approved recently for prevention of episodic and chronic migraine. CGRP is involved in the pathogenesis of migraine, and erenumab works by blocking the CGRP receptors. Common side effects include injection site reactions and constipation. Here we present a patient with hemicrania continua (HC) who responded well to erenumab, while the medication additionally treated her debilitating diarrhea. A 61-year-old female with history of intractable, refractory, chronic, daily, left hemicranial headaches with migrainous features associated with restlessness, ...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Peripheral  mu-opioid receptors (MOR) are responsible for opioid-induced constipation, but in the uninjured state do not participate significantly in the pain pathway. On the other hand, kappa- (KOR) and delta-opioid (DOR) receptors are constitutively present in the periphery. However, the DOR only becomes active following the induction of the inflammatory response. The relative contribution of DOR agonism to KOR agonism was examined in the formalin model. Subcutaneous plantar injection of formalin causes a bi-phasic nocifensive behavioral response in rodents.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Publication date: Available online 20 March 2019Source: Carbohydrate PolymersAuthor(s): Kaidong Li, Lingling Zhu, Huan Li, Yiqing Zhu, Chun Pan, Xiangdong Gao, Wei LiuAbstractA new pectin (ALP-2) was extracted from the roots of Arctium lappa L. with the molecular weight of 1.84 × 106 Da. ALP-2 was composed of rhamnose, glucuronic acid, galacturonic acid, glucose, galactose, xylose and arabinose. Results of NMR revealed that the dominant linkage types of ALP-2 were →4-α-GalpA-6-OMe-(1→, →2-α-Rha-(1→, →5-α-Araf-(1→ and →3,6-β-Galp-(1→. The ELI...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Conclusion: This would assist the researchers to get a better insight into Lentil seeds.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
CONCLUSION: The experience of specific SHCs in the first 6 months after an SCI is related to greater long-term disability. In order to reduce the disability burden of people with SCI, efforts should be directed toward early prevention of these SHCs. PMID: 30882288 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
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