Low vitamin D at ICU admission is associated with cancer, infections, acute respiratory insufficiency and liver failure

25-hydroxyvitamin D (25(OH)D) is synthesised by the skin from 7-dehydrocholesterol in response to sun exposure [1], and can also be obtained through the diet [2]. Both dietary and endogenous vitamin D concentrations are considered biologically inactive. To become active, vitamin D undergoes hydroxylation, initially in the liver by 25-hydroxylase, forming 25(OH)D; subsequently, 25(OH)D undergoes further hydroxylation by 1 alpha-hydroxylase in the kidney and forms 1.25-dihydroxyvitamin D, the active form of vitamin D [3,4].

Source: Nutrition - October 24, 2018 Category: Nutrition Authors: Tatyanne L N Gomes, Renata C Fernandes, Liana L Vieira, Raquel M Schincaglia, Jo ão F Mota, Marciano S Nóbrega, Claude Pichard, Gustavo D Pimentel Source Type: research