Features of Patients Aged 80 Years or Older with Embolic Stroke of Undetermined Source

In this study, we investigated the features of this condition in patients greater than or equal to 80 years of age. Methods: All patients with acute ischemic stroke in our hospital underwent diffusion-weighted imaging, magnetic resonance angiography, T2-weighted imaging, and fluid-attenuated inversion recovery sequence imaging. Embolic stroke of undetermined source was defined as a radiologically confirmed nonlacunar brain infarct on diffusion-weighted imaging without (1) extracranial or intracranial atherosclerosis causing greater than or equal to 50% luminal stenosis in arteries supplying the ischemic area, (2) major-risk cardioembolic source, and (3) any other specific cause of stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research

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We describe the case of a 69 year-old man who presented with repeated episodes of irregular jerking movements in the bilateral upper and lower extremities, precipitated by standing up. Cerebral angiograms revealed occlusion of both internal carotid arteries, and the patient's symptoms responded to targeted blood pressure management. Physicians should be mindful of bilateral limb-shaking TIAs when presented with bilateral paroxysmal events that can mimic seizures or orthostatic hyperkinesia.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Tags: Case Report Source Type: research
ConclusionBaseline cut off thrombus appearance predicts a  higher number of thrombectomy maneuvers. In day to day practice this may prepare the neurointerventionalist for a more challenging endovascular procedure ahead. Stroke etiology, clinical outcomes and thrombus-specific characteristics did not show any associations with the thrombus appearance.
Source: Klinische Neuroradiologie - Category: Radiology Source Type: research
CONCLUSIONS: CDA are not associated with a major occurrence of cerebrovascular events in a high-risk population of hypertensives. PMID: 31782281 [PubMed - as supplied by publisher]
Source: International Angiology - Category: Cardiology Tags: Int Angiol Source Type: research
Background: Extracranial carotid artery (ECA) tortuosity may influences successful recanalization rates of mechanical thrombectomy in acute ischemic stroke (AIS), yet the relationship between ECA tortuosity and the prognosis of patients with anterior circulation AIS who cannot undergo endovascular treatment remains uncertain. We hypothesized that increased tortuosity of the ECA leads to unfavorable outcomes in such patients. Methods: Patients with anterior circulation AIS who underwent computed tomography angiography of the head and neck in our hospital between March 2018 and November 2018 were retrospectively analyzed.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
AbstractDespite the improving imaging techniques, it remains challenging to produce magnetic resonance (MR) imaging fingerprints depicting severity of acute ischemia. The aim of this study was to evaluate the potential of the overall high ‐field1H MR Spectroscopy (1H ‐MRS) neurochemical profile as a metabolic signature for acute ischemia severity in rodent brains.We modeled global ischemia with one ‐stage 4‐vessel‐occlusion (4VO) in rats. Vascular structures were assessed immediately by magnetic resonance angiography (MRA). The neurochemical responses in the bilateral cortex were measured 1h after stroke onset by...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
Introduction: In the context of first screening for pulmonary arteriovenous malformations (PAVM) in Hereditary Hemorrhagic Telangiectasia (HHT), some patients only have isolated micronodules on Chest CT and/or intrapulmonary shunt on Transthoracic Contrast Echocardiography (TTCE), without PAVM on CT or angiography. The aim of this study was to determine the risk of developing genuine PAVM or neurological complications of PAVM in these patients.Material and Methods: We conducted a retrospective study among the 901 patients with HHT followed in the French national reference center for HHT in Lyon, France. Screening results w...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
This study aimed to evaluate the plasma levels of novel adipokines in patients with sICAS and sECAS and their associations with the prognosis of sICAS groups.Methods: A total of 134 patients with acute ischemic stroke attribute to large-artery atherosclerosis (LAA) and 66 age- and sex-matched controls without atherosclerotic stenosis (NCAS) were included in this study. The LAA group was further sub-classified as sICAS (n = 102) and sECAS (n = 32) according to the location of atherosclerosis. Demographics, clinical parameters, angiographical features and plasma levels of novel adipokines (apelin, visfatin, omentin, RBP-4) w...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSION:  We demonstrate that increased clot AUC predicts future cardiovascular events in stable CAD patients receiving aspirin monotherapy. PMID: 31733633 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research
ConclusionIn the present study, the Acclino was associated with a  low risk of thromboembolic complications and high aneurysm occlusion rates at long-term follow-up. Due to incomplete angiographic follow-up in this series, prospective studies will be necessary to confirm the results.
Source: Clinical Neuroradiology - Category: Neurology Source Type: research
Conditions:   Ischemic Stroke;   Carotid Stenosis Interventions:   Other: Carotid duplex+/- MRA neck;   Other: brain MRA+/-CT angio on carotid and brain;   Other: MRI brain;   Other: DSA (digital subtraction angiography) Sponsor:   Mansoura University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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