New Advances in Neuromodulation

AbstractPurpose of ReviewThe purpose of this article is to illustrate the recent advances made in the field of neuromodulation for chronic pain management and it provides a brief review of the literature supporting their safe and efficacious use.Recent FindingsSpinal cord stimulation (SCS) has been an effective therapy for the management of intractable pain conditions including complex regional pain syndrome (CRPS), peripheral neuropathy, and failed back surgery syndrome (FBSS). With the introduction of high-frequency and burst SCS waveforms, there has been a noted improvement in the treatment outcomes of these pain syndromes. Dorsal root ganglion stimulation and peripheral nerve stimulation have made it possible to achieve pain relief in the focal areas of pain, which was difficult before with the use of conventional SCS.SummaryChronic pain conditions afflict a large population and are the leading causes of disability among industrialized nations. Conditions such as CRPS, peripheral neuropathy, and FBSS are often difficult to treat with conservative medical measures. This has been one of the factors that have led to increased opioid prescribing and has contributed to the current opioid crisis. Neuromodulation offers a relatively safe and effective therapy for the chronic pain patients that have failed conservative pain measures or are unwilling to undergo higher risk options such as spine surgery or opioid therapy.
Source: Current Anesthesiology Reports - Category: Anesthesiology Source Type: research

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So in this "fellowship" that i resigned from recently, I asked long time ago whether tail was covered.I was told yes. When I signed paperwork after resigining I was told that I'd be covered for the premium for the tail. When I was like what?! That's not what I was told. I was told that "it would be covered if I finished the fellowship." That seems shady and illegal. Obviously paying thousands of dollars for tail would be reasonable on an attending salary, but now it seems they are pissed I... Tail coverage
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Publication date: Available online 16 November 2019Source: Social Science &MedicineAuthor(s): Henry J. Whittle, Anna M. Leddy, Jacqueline Shieh, Phyllis C. Tien, Ighovwerha Ofotokun, Adaora A. Adimora, Janet M. Turan, Edward A. Frongillo, Bulent Turan, Sheri D. WeiserAbstractMaterial-need insecurities (including insecurities in basic resources such as income, food, housing, and healthcare) are widespread in the United States (US) and may be important predictors of poor health outcomes. How material-need insecurities besides food insecurity are experienced, however, remains under-researched, including how multiple mater...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 17 November 2019Source: Pharmacological ResearchAuthor(s): Victor Fattori, Tiago H. Zaninelli, Fernanda S. Rasquel-Oliveira, Rubia Casagrande, Waldiceu A. VerriAbstractWe now appreciate that the mechanism of resolution depends on an active and time-dependent biosynthetic shift from pro-inflammatory to pro-resolution mediators, the so-called specialized pro-resolving lipid mediators (SPMs). These SPMs are biosynthesized from the omega-3 fatty acids arachidonic acid (AA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), or docosahexaenoic acid (DHA). Despite effective for a fractio...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
This study aimed to investigate the mechanism of action of ginger extract and its compound, 6-shogaol, on pancreatic islets as well as on expressions of TRPV-1 and NMDAR2B in the spinal cord of streptozotocin (STZ)-induced mice model of PDN.Materials and methodsSixty-four 5–6 months old male-Balb/C mice were induced with 110 mg/kgBW STZ i.p., while eight mice were used as control group. Mice with blood glucose level ≥200 mg/d, that suffered hyperalgesia and allodynia were classified as PDN mice. Hot plate and von Frey filament tests were performed once a week until termination. At day 28 after considered as PDN,...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionThe authors recommended short implants whenever the height of available bone permits optimum implant placement. The authors concluded that both treatment options are considered viable clinically and radiographically. However, short implants have shown reduced postoperative discomfort, minimal invasiveness, and reduced cost.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
ConclusionLimited available evidence suggests that patients with RAS may experience a reduction in the number of ulcers, DOU, NOE, and UP when using a SLS-free dentifrice as compared to using a dentifrice containing SLS.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
This study is an attempt to investigate the effects of intrathecal administration of Melissa officinalis on the pain induced by heat and formalin.In this experimental study, seventy male Wistar rats with an average weight of 270-320 g were randomly divided into 5 groups: control; sham, that received 25 μl of saline through the spinal catheter; and three experimental groups, that received 5, 10 or 20 mg/kg Melissa officinalis via the spinal catheter respectively. Five days after catheterization of the spinal cord from the lumbar region under anesthesia, the effects of Intrathecal administration of Melissa officinalis on ...
Source: Journal of Acupuncture and Meridian Studies - Category: Complementary Medicine Source Type: research
ConclusionsThe PCV-VG mode of ventilation limited the peak inspiratory pressure, decreased the driving pressure and increased the dynamic compliance compared to VCV in obese patients undergoing laparoscopic hysterectomy. PCV-VG may be a preferable modality to prevent barotrauma during laparoscopic surgeries in obese patients.ResumoJustificativa e objetivosO objetivo deste estudo foi investigar a eficácia dos modos de ventilação garantida por volume controlado por pressão (PCV-VG) e ventilação controlada por volume (VCV) para manter pressões adequadas nas vias aéreas, ...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Conclusions and ImplicationsAlthough group differences were not found when considering parent-reported sleep problems, more frequent sleep problems were positively associated with increased forgetting by children with DS relative to those who were TD. Although future experimental work is needed to determine causality, these results suggest that improved sleep in children with DS might reduce forgetting, ultimately improving long-term recall memory.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
A 56-year-old automobile mechanic was referred to our rheumatology service by his orthopedist to evaluate left posterior knee pain and swelling that had been present for three months. The patient had undergone bilateral total knee arthroplasties (TKAs) for sports-related osteo­arthritis three years before. In addition to the knee pain, the patient described several years of... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Home Slider Rheumatoid Arthritis knee arthroplasty knee swelling popliteal cyst synovitis Source Type: research
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