Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients: A Randomized Clinical Trial

This research article found the use of chlorhexidine mouthwash, selective oropharyngeal decontamination or selective digestive tract decontamination was not linked to reductions in ICU-acquired bloodstream infections caused by multidrug-resistant gram-negative bacteria vs. standard care.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Ticagrelor is a reversible platelet adenosine diphosphate P2Y12 receptor (P2Y12) inhibitor and is quite effective as an antiplatelet agent. New research suggests an antibiotic effect for ticagrelor and the researchers suggest that further research may lead to development of a new class of antibiotics [1]. In fact there is a global need for new antibiotics, which are conspicuous by their absence in the current scenario of multidrug resistant organisms. The study published as a Research Letter in JAMA Cardiology reports on the ‘Antibacterial Activity of Ticagrelor in Conventional Antiplatelet Dosages Agains...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Source Type: blogs
In conclusion, allicin results in an oxidative shift of EBSH and protein S-thioallylation, which can be reversed by YpdA and the Brx/BSH/YpdA electron pathways in S. aureus to regenerate thiol homeostasis. PMID: 31121222 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - Category: Biology Authors: Tags: Free Radic Biol Med Source Type: research
This study demonstrates that corvids can be reservoirs and vectors of ARE and pathogenic E. coli, posing a significant environmental threat.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Authors: Kulkarni AP, Nagvekar VC, Veeraraghavan B, Warrier AR, Ts D, Ahdal J, Jain R Abstract The emerging antimicrobial resistance leading to gram-positive infections (GPIs) is one of the major public health threats worldwide. GPIs caused by multidrug resistant bacteria can result in increased morbidity and mortality rates along with escalated treatment cost and hospitalisation stay. In India, GPIs, particularly methicillin-resistant Staphylococcus aureus (MRSA) prevalence among invasive S. aureus isolates, have been reported to increase exponentially from 29% in 2009 to 47% in 2014. Apart from MRSA, rising preva...
Source: Interdisciplinary Perspectives on Infectious Diseases - Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research
ConclusionsThe availability of this genome will allow gaining insights into the S. aureus resistance and virulence determinants, as well as its epidemiology, lineage, evolution, and genomic features involved in the infantile commensal carriage.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsIn summary, compound 35 was identified as a new lead aryl isonitrile compound that warrants further investigation as a novel antibacterial agent.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Abstract The major multidrug-resistant pathogens (MRE) in human medicine are methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) and multidrug-resistant Gram-negative rod bacteria (MRGN). MRE are a very heterogeneous group with respect to epidemiology and therapeutic or hospital hygiene consequences. After MRSA played an important role among MREs at the beginning of the twenty-first century, VRE and MRGN have come to the fore in recent years. During work in the operating room and on the intensive care unit, there are many possibilities for transmission of MRE between the...
Source: Der Anaesthesist - Category: Anesthesiology Authors: Tags: Anaesthesist Source Type: research
Tichý J, Birošová L Abstract Wastewater contains subinhibitory concentrations of different micropollutants such as antibiotics that create selective pressure on bacteria. This phenomenon is also caused by insufficient wastewater treatment technology leading to the development and spread of antibiotic-resistant bacteria and resistance genes into the environment. Therefore, this work focused on monitoring of antibiotic-resistant coliform bacteria and enterococci in influent and effluent wastewaters taken from the second biggest wastewater treatment plant (Petržalka) in the capital of Slovakia ...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
Conclusion In conclusion, our systematic study shows two possible roles of porins, the transport of antibiotics and the membrane integrity regulation, which differently affect antibiotic resistance, and the distinct role of each porin. This provides an important insight to understand not only the role of each porin as a functionally important component of the outer membrane, but also its specific role in the survival of the pathogen under the action of antibiotics. Data Availability All datasets generated for this study are included in the manuscript and/or the Supplementary Files. Author Contributions C-RL contribute...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion: New carbapenem/βLI combinations may be viable alternatives to antimicrobial combination therapy as they displayed high efficacy in vitro and in vivo. Meropenem/Avibactam and Meropenem/Relebactam should be tested on larger sample sizes with different carbapenemases before progressing further in its preclinical development. Introduction Carbapenem resistant Gram-negative bacteria have been gradually increasing in prevalence in recent years. In the United States, the latest CDC Antibiotic Resistance Threat Report indicates that Carbapenem-Resistant Enterobacteriaceae (CREs) are responsible for 9,000 a...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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