Nanotechnology Enabled Inhalation of Bio-therapeutics for Pulmonary Diseases: Design Considerations and Challenges

AbstractPurpose of ReviewThis review aims to critically discuss design considerations for the development of nanoparticle-based formulations for inhalation delivery of bio-therapeutics in pulmonary diseases. We will also discuss the challenges towards clinical translation of this approach, highlighting the directions for future research.Recent FindingsNanotechnology-based inhalation delivery of bio-therapeutics in pulmonary diseases can potentially overcome the shortcomings of clinically used parenteral route. Exploration of inhalable nanoparticles for delivery of bio-therapeutics in pulmonary diseases is still at an early stage. While most of these approaches have been developed for the delivery of nucleic acids, a few have focused on delivering monoclonal antibodies and proteins. However, multiple challenges need to be addressed for successful translation of this approach.SummaryWe summarize the design considerations and challenges that may help in creating a roadmap for the development of clinically translatable nanoparticle-based inhalable formulations of bio-therapeutics for pulmonary diseases.
Source: Current Pathobiology Reports - Category: Laboratory Medicine Source Type: research