β-hydroxy-β-methylbutyrate (HMB) improves mitochondrial function in myocytes through pathways involving PPARβ/δ and CDK4

Mitochondria are normally regarded as the “power house” of the cell and provide adenosine triphosphate (ATP) for cellular metabolic activity [1]. In addition, mitochondria are implicated in the modulation of skeletal muscle fiber size, metabolism, and function [2]. In particular, increased mitochondrial content and function is closely a ssociated with enhanced oxidative capacity of muscle fibers, leading to improved muscle health and whole-body health and wellbeing [3]. Therefore, the increased mitochondrial content and function may partially contribute to the positive effects of elevated muscle oxidative capacity in disease states , such as obesity and diabetes [4, 5].

Source: Nutrition - October 23, 2018 Category: Nutrition Authors: Yinzhao Zhong, Liming Zeng, Jinping Deng, Yehui Duan, Fengna Li Source Type: research