Major depression and atrial natriuretic peptide: the role of adverse childhood experiences

Neuroendocrine peptides have been increasingly acknowledged in psychiatric research due to their actions in the central nervous system (CNS) (Bandelow et al., 2017). Atrial natriuretic peptide (ANP) is a 28 amino acid peptide, which is synthesised in cardiomyocytes and acts in the context of blood pressure regulation. Reduced basal ANP levels have been associated with cardiovascular disease, overweight, hypertension, and insulin resistance (Wis én et al., 2011). In the CNS, ANP is expressed in the hypothalamus, brainstem, cerebellum, and cerebral cortex (Meyer and Herrmann-Lingen, 2018).
Source: Psychoneuroendocrinology - Category: Psychiatry Authors: Tags: Short Communication Source Type: research