Relationship of common variants in CHRNA5 with early-onset schizophrenia and executive function

Altered cholinergic neural transmission is hypothesized to increase susceptibility to cognitive deficits in psychotic disorders such as schizophrenia (SCZ). The nicotinic acetylcholine receptor α5 subunit gene (CHRNA5) is reported to be associated with cognitive function in nicotine-dependent populations and SCZ in non-smoking SCZ patients. Nevertheless, it is still not clear whether the CHRNA5 gene contributes to susceptibility to the cognitive deficits of SCZ without smoking. To further clarify the role of CHRNA5, we designed a two-stage, case-control study to examine the association between CHRNA5 and SCZ and its clinical features adjusted for smoking status in early-onset SCZ patients.

Source: Schizophrenia Research - October 23, 2018 Category: Psychiatry Authors: Wei Han, Tianxiao Zhang, Tong Ni, Li Zhu, Dan Liu, Gang Chen, Huali Lin, Teng Chen, Fanglin Guan Source Type: research