Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study

Publication date: Available online 22 October 2018Source: The Lancet Respiratory MedicineAuthor(s): Robinder G Khemani, Lincoln Smith, Yolanda M Lopez-Fernandez, Jeni Kwok, Rica Morzov, Margaret J Klein, Nadir Yehya, Douglas Willson, Martin C J Kneyber, Jon Lillie, Analia Fernandez, Christopher J L Newth, Philippe Jouvet, Neal J Thomas, Pediatric Acute Respiratory Distress syndrome Incidence and Epidemiology (PARDIE) Investigators, Eugenia Abaleke, Kate G Ackerman, Carlos Acuña, Michelle Adu-Darko, Jeremy T Affolter, Rachel AgbekoSummaryBackgroundPaediatric acute respiratory distress syndrome (PARDS) is associated with high mortality in children, but until recently no paediatric-specific diagnostic criteria existed. The Pediatric Acute Lung Injury Consensus Conference (PALICC) definition was developed to overcome limitations of the Berlin definition, which was designed and validated for adults. We aimed to determine the incidence and outcomes of children who meet the PALICC definition of PARDS.MethodsIn this international, prospective, cross-sectional, observational study, 145 paediatric intensive care units (PICUs) from 27 countries were recruited, and over a continuous 5 day period across 10 weeks all patients were screened for enrolment. Patients were included if they had a new diagnosis of PARDS that met PALICC criteria during the study week. Exclusion criteria included meeting PARDS criteria more than 24 h before screening, cyanotic heart disease, active perinatal lung ...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research