Second proton therapy system coming to Barnes Jewish Hospital in early 2020

A new type of medical scanning technology that would provide precise, radiation therapy for cancer patients will be coming to Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis in 2020. The technology known as pencil-beam scanning will deliver extremely precise treatments of proton therapy, a type of radiation therapy used to treat cancers of the head, chest, spine and other sensitive areas, as well as pediatric cancers. Siteman Cancer Center is also the home to another…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Proton therapy has an important role in the management of head and neck cancer, where the dosimetric characteristics of proton particles are advantageous for treating tumors in complex anatomic areas. In addition to highly targeted dose depositions owing to the Bragg peak and superior lateral dose distribution of proton therapy, the introduction of spot-scanning techniques that allow intensity-modulated proton therapy (IMPT) further improve dose distributions and normal-tissue sparing relative to intensity-modulated (photon) radiation therapy (IMRT), a finding that has been validated in case-matched analyses showing lower ...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
1139Introduction: Thoracic malignancies are among the most common malignancies diagnosed both in the United States and worldwide. Radiation therapy (RT) plays an important role in the treatment of thoracic malignancies. Depending on the primary disease site and tumor stage, RT can be used as monotherapy, or as part of multimodality therapy for curative intent, or for palliative reduction of advanced disease. In fact, more than 50% of all patients with thoracic malignancies will receive RT as part of their multidisciplinary care. 18F-Fluorodeoxyglucose positron emission tomography (PET) is commonly used for initial cancer d...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibit Posters Source Type: research
CONCLUSIONS: The breath-hold technique is robust to residual intra-breath-hold motion for SFUD treatment plans, based on our experimental study. IMPT was less robust with larger detected dose deviations. PMID: 31005207 [PubMed - in process]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
We report the early clinical outcomes and toxicities of intensity-modulated proton therapy (IMPT) vs. intensity-modulated radiation therapy (IMRT) in patients with locally-advanced NSCLC.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
In this study, we evaluate the potential reduction in radiation-induced skin morbidity obtained by intensity modulated proton therapy (IMPT) compared with intensity modulated photon therapy (IMXT) for left-side BC and RNI. MATERIAL AND METHODS: Using CT scans from 10 left-side BC patients, treatment plans were generated using IMXT and IMPT techniques. A dose of 50 Gy (or Gy [RBE] for IMPT) was prescribed to the target volume (involved breast, the internal mammary, supraclavicular, and infraclavicular nodes). Two single filed optimization IMPT (IMPT1 and IMPT2) plans were calculated without and with skin optimiz...
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
Postmastectomy radiation therapy (PMRT) has consistently shown benefits in decreasing the risk of locoregional recurrence and increasing long-term breast cancer-specific survival and overall survival rates for high-risk node positive breast cancer [1 –3]. A standard PMRT field includes chest wall and comprehensive coverage of the axillary and supraclavicular lymph nodes. The addition of internal mammary chain in the radiation field has been increasingly adopted and supported by data from randomized clinical trials [4–6].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Source Type: research
1224Aim:Radeation therapy (RT) is an important component of cancer treatment for both early stage and locally advanced lung cancers. Photon and proton therapies are both utilized for RT but have different physical characteristics. Photon RT actively exposes healthy tissues along the beam path in front of and beyond the tumor to incidental irradiation. However, due to a central-axis depth-dose distribution pattern known as the spread-out Bragg peak (SOBP), proton RT generally has a more optimal dose delivery in comparison to 3D conformal photon therapy and intensity-modulated radiation therapy (IMRT). The SOBP may potential...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibits Source Type: research
CONCLUSION: For the studied liver case, intrafractional motion did not reduce the modulation of the RBE-weighted dose postulated by variable RBE models for proton treatments. PMID: 28828913 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
Conclusions For left-sided PMRT, passively scattered or PBS protons with or without DIBH improves homogeneity and cardiopulmonary sparing without compromise in target coverage compared with PWTF photons with DIBH. Furthermore, the addition of DIBH to proton therapy did not provide a significant dosimetric benefit.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Conclusion For left-sided PMRT, passively scattered or PBS protons with or without DIBH improves homogeneity and cardiopulmonary sparing without compromise in target coverage compared to PWTF photons with DIBH. Furthermore, the addition of DIBH to proton therapy did not provide a significant dosimetric benefit.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
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