Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages

The metabolic-inflammatory crosstalk plays a key role in host defense against pathogens and inflammation. Guo and colleagues demonstrate that SCAP-SREBP2 complex integrates NLRP3 inflammasome activation and cholesterol biosynthetic signaling during inflammation.

Source: Immunity - October 23, 2018 Category: Allergy & Immunology Authors: Chuansheng Guo, Zhexu Chi, Danlu Jiang, Ting Xu, Weiwei Yu, Zhen Wang, Sheng Chen, Li Zhang, Qianyun Liu, Xingchen Guo, Xue Zhang, Wenxin Li, Linrong Lu, Yingliang Wu, Bao-Liang Song, Di Wang Tags: Article Source Type: research