Selective CH bond functionalization with engineered heme proteins: new tools to generate complexity.

Selective CH bond functionalization with engineered heme proteins: new tools to generate complexity. Curr Opin Chem Biol. 2018 Oct 18;49:67-75 Authors: Zhang RK, Huang X, Arnold FH Abstract CH functionalization is an attractive strategy to construct and diversify molecules. Heme proteins, predominantly cytochromes P450, are responsible for an array of CH oxidations in biology. Recent work has coupled concepts from synthetic chemistry, computation, and natural product biosynthesis to engineer heme protein systems to deliver products with tailored oxidation patterns. Heme protein catalysis has been shown to go well beyond these native reactions and now accesses new-to-nature CH transformations, including CN and CC bond forming processes. Emerging work with these systems moves us along the ambitious path of building complexity from the ubiquitous CH bond. PMID: 30343008 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research