New Stem Cell Research Aims To Stop Boys Losing Fertility After Childhood Cancer Treatment

Young boys are often left infertile after childhood cancer treatment, with no way of preserving their sperm. Now, new research might allow them to father children.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news

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ConclusionsIn a sample of women's health providers across multiple different OB/GYN specialties, there was an overall supportive response towards PGT use for a variety of common indications. Infertility specialists were the most supportive of PGT use, which may reflect the familiarity these providers have with this procedure. There was an overwhelmingly non-supportive response to the use of PGT for non-disease related indications. The percentage of medical professionals working in women's health without prior knowledge of PGT (22.5%) is higher than expected, identifying the need for more education regarding the availabilit...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
ConclusionsWe recommend developing collaborative initiatives to build a regional repository of systematically assessed health outcomes and biospecimens to investigate treatment, social-environmental and genetic predictors, and interventions for late effects in this population.Implications for Cancer SurvivorsThe existing types of chronic health problems identified in this review suggest the need for active screening, better access to survivorship care, and promotion of protective health behavior in Asia.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
In this study, we reviewed major human studies on the health risks of radiation exposure and showed that sex-related factors may potentially influence the long-term response to radiation exposure. Available data suggest that long-term radiosensitivity in women is higher than that in men who receive a comparable dose of radiation. The report on the biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences, United States emphasized that women may be at significantly greater risk of suffering and dying from radiation-induced cancer than men exposed to the same dose of radiation....
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Preterm birth could double risk of kidney disease into mid-adulthood Related items fromOnMedica Infertility much more likely after childhood cancer Foetal alcohol syndrome must be better recognised Teens more likely to have an abortion if their mother did Stillbirth risk doubled in women sleeping on their back Doctors should regard FGM as child abuse
Source: OnMedica Latest News - Category: UK Health Source Type: news
In this study, a link between mitochondrial changes and infant temperament has also been suggested. Maternal psychosocial stress and lifetime trauma have been associated with decreased mitochondrial DNA copy number in the placenta (115, 116).IndividualityChronic stress links changes in the epigenetic landscape with health conditions (117). Different cell types are characterized by distinct patterns of gene expression due to developmental, environmental, physiological, and pathological reasons (117). Epigenetic mechanisms affect gene function in a dynamic way as a result of different environmental exposures during fetal dev...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
(University of Michigan) Leukemia treatments often leave girls infertile, but a procedure developed by researchers at the University of Michigan working with mice is a step toward restoring their ability to be biological mothers.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Children born through IVF have slight increased risk of certain childhood cancers during first decade of life, study finds Related items fromOnMedica Infertility much more likely after childhood cancer Higher heart risk for survivors of childhood cancer One in 10 children in phase I cancer trials respond to drugs Foetal alcohol syndrome must be better recognised Review reveals young cancer patients are put at risk
Source: OnMedica Latest News - Category: UK Health Source Type: news
ConclusionsPerinatal and early-life risk factors, and specifically indicators of brain trauma, exposure to toxic agents and immune system maturation, might be involved in the pathogenesis of childhood brain tumors. Larger studies should aim to replicate our findings and examine associations with tumor subtypes.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Abstract A balanced Robertsonian translocation results from fusion of two acrocentric chromosomes. Carriers are phenotypically normal, and are often diagnosed because of recurrent miscarriages, infertility or aneuploid offspring. Mortality and site-specific cancer risks in carriers have not been prospectively investigated. We followed 1987 carriers diagnosed in Great Britain for deaths and cancer risk, over an average of 24.1 years. Standardised mortality (SMR) and incidence (SIR) ratios were calculated comparing the number of observed events against population rates. Overall mortality was raised for carriers diagnosed aged
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
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