Next-generation antigen receptor sequencing of paired diagnosis and relapse samples of B-cell acute lymphoblastic leukemia: clonal evolution and implications for Minimal Residual Disease target selection

Antigen receptor (immunoglobulin (IG) and T-cell receptor (TR)) gene rearrangements can be considered as DNA fingerprints of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells. Consequently, they are frequently used to monitor minimal residual disease (MRD) in BCP-ALL patients [1]. However, IG/TR gene rearrangements can be lost during the course of the disease due to outgrowth of subclones, ongoing rearrangements or secondary rearrangements, thereby resulting in false-negative MRD results [2 –8].

Source: Leukemia Research - October 22, 2018 Category: Hematology Authors: Prisca M.J. Theunissen, Maaike de Bie, David van Zessen, V. de Haas, Andrew P. Stubbs, Vincent H.J. Van Der Velden Tags: Research paper Source Type: research