Distinct monocyte subset phenotypes in patients with different clinical forms of chronic Chagas disease and seronegative dilated cardiomyopathy

Conclusions/SignificanceThe different clinical stages of chronic Chagas disease display distinct monocyte profiles that are restored after anti-parasite drug therapy.T.cruzi-infected subjects with severe cardiac disease displayed a profile of monocytes subsets suggestive of a more pronounced inflammatory environment compared with subjects suffering from heart failure not related toT.cruzi infection, supporting that parasite persistence might also alter cell components of the innate immune system.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research