Alzheimer ’s Amyloid-Beta Intermediates Generated by Polymer-Nanodiscs

Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C8CC07921H, CommunicationBikash Sahoo, Takuya Genjo, Michael Bekier II, Sarah N Cox, Andrea Stoddard, Magdalena Ivanova, Kazuma Yasuhara, CA Fierke, Yanzhuang Wang, Ayyalusamy Ramamoorthy Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (~10 nm) and macro-nanodiscs (>15 nm) are used to study A β1-40 aggregation. We demonstrate that PMA-nanodiscs form a ternary association with Aβ and regulate its aggregation... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research