An update on the role of RANKL-RANK/osteoprotegerin and WNT- ß-catenin signaling pathways in pediatric diseases.

CONCLUSIONS: The case studies taken into account for this review demonstrated that quite frequently both bone reabsorbing and bone deposition are impaired in pediatric diseases. Furthermore, for some of them, bone damage began in childhood but only manifested with age. The use of denosumab could represent a valid alternative therapeutic approach to improve bone health in children, although further studies need to be carried out.
PMID: 30343446 [PubMed - as supplied by publisher]

Source: World Journal of Pediatrics : WJP - October 20, 2018 Category: Pediatrics Authors: Brunetti G, D'Amato G, Chiarito M, Tullo A, Colaianni G, Colucci S, Grano M, Faienza MF Tags: World J Pediatr Source Type: research