Grown stem cells may help men infertile from childhood cancer treatment
Researchers have figured out how to grow human stem cells to help children treated for cancer who become infertile later in life.
Abstract A balanced Robertsonian translocation results from fusion of two acrocentric chromosomes. Carriers are phenotypically normal, and are often diagnosed because of recurrent miscarriages, infertility or aneuploid offspring. Mortality and site-specific cancer risks in carriers have not been prospectively investigated. We followed 1987 carriers diagnosed in Great Britain for deaths and cancer risk, over an average of 24.1 years. Standardised mortality (SMR) and incidence (SIR) ratios were calculated comparing the number of observed events against population rates. Overall mortality was raised for carriers diagnosed aged
AbstractChemotherapy-induced gonadal dysfunction resulting in transient or persistent infertility depends on the type of drugs and cumulative dose, and it is an important long-term complication, especially for adolescent and young adult (AYA) cancer patients. Due to its importance, a clinical practice guideline for fertility preservation in childhood and AYA cancer patients was published by the Japan Society of Clinical Oncology (JSCO) in 2017. Although the precise mechanisms remain unclear, several studies reported that the cancer itself, not the cancer treatment, adversely affected semen quality. It is reported that that...
Young boys are often left infertile after childhood cancer treatment, with no way of preserving their sperm. Now, new research might allow them to father children.
In a large Australian study, researchers found that baby boys born with undescended testes had a higher risk of health problems like infertility and cancer, especially if corrective surgery was delayed.
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The purpose of this study was to evaluate the effectiveness of a personalized educational intervention to increase adolescent and young adult (AYA) cancer survivors ’ knowledge of their risk for infertility and to determine their preferences for further education.
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Publication date: April 2018Source: Best Practice &Research Clinical Obstetrics &Gynaecology, Volume 48Author(s): Gabriela N. Algarroba, Joseph S. Sanfilippo, Hanna Valli-PulaskiAbstractThe 5-year survival rate for childhood cancer is over 80%, thereby increasing the number of young women facing infertility in the future because of the gonadotoxic effects of chemotherapy and radiation. The gonadotoxic effects of childhood cancer treatment vary by the radiation regimen and the chemotherapeutic drugs utilized. Although the American Society of Clinical Oncology guidelines recommend fertility preservation for all patie...
Many survivors of childhood cancer will experience premature gonadal insufficiency or infertility as a consequence of their medical treatments. Ovarian tissue cryopreservation (OTC) remains an experimental means of fertility preservation with few reports focused on the surgical technique and postoperative outcomes for OTC in children.
ConclusionAlthough this population of women has above average knowledge scores, they still demonstrated a desire for more information on reproduction after cancer therapy. While PedsQL scores fell within a normal range, survivors report infertility would cause negative emotions.Implication for cancer survivorsThis information can be used refine educational programs within survivorship clinics to improve knowledge of post-treatment reproductive health.