Celiac Disease —Musculoskeletal Manifestations and Mechanisms in Children to Adults

AbstractPurpose of ReviewWe aim to review the current literature on the association of musculoskeletal disorders and celiac disease that is a common disorder, affecting about 1% of the population. Extra-intestinal symptoms and presentations predominate.Recent FindingsWhile the literature supports an association with reduced bone mineral density and increased fracture risk and celiac disease, there is little evidence supporting associations with other rheumatological conditions. Patients frequently report musculoskeletal symptoms; however, studies of specific disease entities suffer from a lack of standardization of testing for celiac disease and a lack of control groups.SummaryWell-controlled, preferably population-based studies are required to further explore a relationship between celiac disease and musculoskeletal disorders.
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research

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Conclusions: The persistent activation of inflammation should be considered the main pathophysiological mechanism for bone defect in celiac disease patients with bone loss on long-term GFD. High levels of OPG, an attempt at protective mechanism, and low levels of propeptide of type I procollagen, reflecting an insufficient matrix production, characterize this subgroup of patients.
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research
We pay special attention to restoration of magnesium in the Wheat Belly lifestyle. This is because magnesium deficiency is universal, affecting virtually everyone, is severe, and has substantial implications for health. But why? Why has everyone become so depleted in magnesium in the modern world? There are five major reasons: Water filtration—We filter our water out of necessity, since modern waterways are contaminated by sewage runoff, pesticide/herbicides, algal overgrowth, etc. So, rather than drinking from a nearby stream or river that runs freely over rocks and minerals rich in magnesium, we drink water filter...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Magnesium grain-free phytates undoctored wheat belly Source Type: blogs
Guidelines advise measurement of bone mineral density (BMD) in patients with a diagnosis of celiac disease. The lumbar spine (LS) and hip sites are usually measured. Although skeletal sites rich in trabecular bone are believed to be vulnerable to osteoporosis in patients with celiac disease, most studies have not measured the cortical distal 1/3-radius.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
CONCLUSION: HLA-DQ2/DQ8 can be used to diagnose celiac disease particularly when the tests are useless and to screen first-degree relatives. PMID: 30945642 [PubMed - in process]
Source: The Turkish Journal of Gastroenterology - Category: Gastroenterology Authors: Tags: Turk J Gastroenterol Source Type: research
The objective of this study was to describe the current state of CD diagnosis and treatment patterns. A targeted review of literature from MEDLINE, Embase, the Cochrane Library, and screening of relevant conference abstracts was performed. The generally recommended diagnostic approach is GI endoscopy with small bowel biopsy; however, in selected patients, biopsy may be avoided and diagnosis based on positive serology and clinical symptoms. Diagnosis often is delayed; the average diagnostic delay after symptom onset is highly variable and can last up to 12  years. Barriers to accurate and timely diagnosis include atypi...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Publication date: Available online 11 February 2019Source: Trends in Food Science &TechnologyAuthor(s): Aybuke Ceyhun Sezgin, Nevin SanlierAbstractBackgroundThe quinoa herb belongs to the family of Chenopodiaceae where spinach and beet are also found. It is a kind of herb that is native to South America and there are about 250 kinds of Chenopodium species worldwide. It is considered a sacred herb by humans due to the high level of protein in its composition and its content of essential amino acids in a balanced manner. In addition, due to the fact that quinoa has a high value of energy and nutrients and because of its ...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Celiac disease (CD) is known as a reason of metabolic osteopathy. Progression of non-invasive methods such as bone densitometry has shown that an important ratio of CD cases is faced with impaired bone mass an...
Source: Nutrition Journal - Category: Nutrition Authors: Tags: Review Source Type: research
Abstract Celiac disease (CD) is the most common autoimmune enteropathy worldwide. In CD, dietary gluten triggers a T cell driven small intestinal inflammation in a subset of genetically predisposed subjects, expressing the HLA DQ2 and/or DQ8 genes on their antigen presenting cells. HLA DQ2/DQ8 can bind gluten peptides after their prior modification by the CD autoantigen, tissue transglutaminase (TG2). This process leads to the activation of gluten reactive T cells, small bowel villous atrophy, crypt hyperplasia and intraepithelial lymphocytosis, the histological hallmarks of CD. The clinical picture of CD is extre...
Source: European Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Eur J Intern Med Source Type: research
Are individuals with celiac disease at increased risk for osteoporosis?Alimentary Pharmacology &Therapeutics
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news
CONCLUSIONS: There were no significantly increased odds of CD in adult patients with fractures compared to controls; however, results imply that positive IgA TG2 is more prevalent in fracture patients than in controls. This study indicates that universal screening for CD in fracture patients is not warranted, but supports current clinical practice in Norway to suspect and investigate for CD in patients with fracture, osteoporosis and other risk factors for CD. PMID: 30265163 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
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