Accomplishments and challenges in stem cell imaging in vivo.

Accomplishments and challenges in stem cell imaging in vivo.
Drug Discov Today. 2018 Oct 17;:
Authors: Bose RJC, Mattrey RF
Abstract
Stem cell therapies have demonstrated promising preclinical results, but very few applications have reached the clinic owing to safety and efficacy concerns. Translation would benefit greatly if stem cell survival, distribution and function could be assessed in vivo post-transplantation, particularly in patients. Advances in molecular imaging have led to extraordinary progress, with several strategies being deployed to understand the fate of stem cells in vivo, for example using magnetic resonance, scintigraphy, PET, ultrasound and optical imaging. Here, we review the recent advances, challenges and future perspectives and opportunities in stem cell tracking and functional assessment, as well as the advantages and challenges of each imaging approach.
PMID: 30342245 [PubMed - as supplied by publisher]

Source: Drug Discovery Today - October 17, 2018 Category: Drugs & Pharmacology Authors: Bose RJC, Mattrey RF Tags: Drug Discov Today Source Type: research