Nanoparticles Based Drug Delivery for Tissue Regeneration Using Biodegradable Scaffolds: a Review

AbstractPurpose of ReviewToday, tissue engineering is advancing rapidly due to application of technologies like computer-aided designing; solid free-form fabrication, nanomedicine, etc. Excessive requirement of artificial organs like skin, blood vessels, cartilage, bladder, etc. is helping in its rapid development. Nanomedicines are used to bind/encapsulate in porous biodegradable scaffolds in the form of antibiotics, proteins, growth factors, specific micro- and macro-nutrients to promote the tissue regeneration.Recent FindingsIn our recent study, we reported that the chitosan-silver-based nanocomposite supports the growth of skin tissues and acts as an antibiotic agent. It was also reported that silver nanoparticles loaded with chitosan and collagen are helpful in regulating macrophage activation and migration of fibroblast.SummaryThis review highlights the application of nanomedicines in biodegradable porous tissue scaffolds applied for organ regeneration.
Source: Current Pathobiology Reports - Category: Laboratory Medicine Source Type: research