Accidental falling in community-dwelling elderly with chronic kidney disease - Goto NA, Hamaker ME, Willems HC, Verhaar MC, Emmelot-Vonk MH.

PURPOSE: The aim of the current study was to evaluate the association between a decreased estimated glomerular filtration rate (eGFR) and accidental falling in elderly patients who visited the day clinic of the department of geriatric medicine of the Unive...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

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CONCLUSIONS: In patients with T2DM and CKD, SGLT2 inhibitors have a decreased glucose-lowering effect compared to patients without CKD. Renal benefits among patients with CKD are similar to those without CKD and include a significant reduction in albuminuria and reduced incidence of worsening albuminuria. Given that CKD and T2DM are both associated with increased cardiovascular risk, we believe these agents should considered as preferred add-on agents in most patients with uncontrolled T2DM and eGFR>30 ml/min/1.73m2. Ongoing studies will provide additional information as to whether these agents should be added to the cu...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
(Children's National Health System) Myriad biological and societal factors can impact the occurrence and accelerate progression of chronic kidney disease for children of African descent - including preterm birth, exposure to toxins during gestation and lower socioeconomic status -- and can complicate these children's access to effective treatments.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
An epidemic of chronic kidney disease (CKD) of unknown etiology, known as Mesoamerican Nephropathy (MeN), has been ongoing in Latin America for at least two decades. MeN primarily affects young adults without traditional CKD risk factors, and agricultural workers are disproportionately afflicted. We previously identified an acute phase of MeN that involves acute kidney injury (AKI) with tubulointerstitial nephritis and systemic inflammation. Because clinical disease progression in MeN is not yet understood, we sought to determine clinical predictors for progression from acute MeN to CKD.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Clinical Investigation Source Type: research
The number of readings needed from ambulatory blood pressure monitoring to diagnose hypertension or determine adequacy of blood pressure control, is largely based on opinion and is not consistent among major guidelines. To address this issue empirically, Agarwal and Tu examined 24-hour ambulatory blood pressure data from 360 individuals who had chronic kidney disease and hypertension, and 38 healthy controls. Almost all were white males. They determined that 15 randomly selected or 40 serial recordings of systolic or diastolic blood pressure taken over a 24-hour period is sufficient to accurately evaluate blood pressure control.
Source: Kidney International - Category: Urology & Nephrology Tags: In This Issue Source Type: research
Hepatitis C virus and the kidney, Published online: 19 November 2018; doi:10.1038/s41581-018-0081-8This Review describes the epidemiology and mechanisms underlying the reciprocal relationship between hepatitis C virus (HCV) infection and chronic kidney disease (CKD). The authors also discuss recommended treatment approaches for patients with HCV infection and CKD, and outline remaining issues in the field.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research
This study aimed...
Source: Journal of Translational Medicine - Category: Research Authors: Tags: Research Source Type: research
AbstractA 57-year-old woman with pre-dialysis chronic kidney disease (CKD) was hospitalized because of fever and fatigue. On admission, increased inflammatory response and pyuria with bacteriuria were observed. Pyelonephritis was successfully treated with antibiotics, whereas her fatigue continued and she developed progressive hypercalcemia and hyponatremia; serum sodium level, 116  mEq/L and corrected serum calcium level, 13.4 mg/dL. Plasma concentrations of adrenocorticotropic hormone and cortisol and serum luteinizing hormone were under the detection level. Although the reaction of other anterior pituitary hor...
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
ConclusionMost studies reported that OPN expression is elevated in urolithiasis, and also in acute and chronic kidney diseases, and in renal allograft dysfunction. Moreover, it was demonstrated that polymorphic variants of the OPN gene may be associated with renal failure. However, some reports suggested that OPN is essential for tubulogenesis, and that it inhibits calcium oxalate crystal formation and retention, nitric oxide synthesis, cell apoptosis and promotes cell regeneration.Thus, further studies are required to fully understand the role of OPN in kidney physiology and pathology. Eventually, these studies may result...
Source: Inflammation Research - Category: Research Source Type: research
Abstract Eicosanoids are biologically active molecules that are created in the process of oxidation of arachidonic acid (AA) which is a constituent of the cell membrane phospholipids. Throughout the years it was evidenced by experiments that the lipid and lipid-derived metabolites play an important role in physiological and pathological processes in the kidneys. They are being considered as biomarkers in detecting acute kidney injury, nephrotoxicity, glomerulonephritis and early stages of diabetic nephropathy because of their participation in inflammatory processes and in oxidative stress. They might be also consi...
Source: Acta Biochim Pol - Category: Biochemistry Authors: Tags: Acta Biochim Pol Source Type: research
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