Erdosteine: Drug exhibiting polypharmacy for the treatment of respiratory diseases

Publication date: Available online 21 October 2018Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Roberto Dal Negro, Edoardo Pozzi, Silvano G. CellaAbstractMucoactive drugs are commonly used in the treatment of acute respiratory tract diseases, such as lower and acute respiratory infection and chronic bronchitis (CB) or chronic obstructive pulmonary disease (COPD) in which an increased mucus secretion is one of main clinical features. Indeed these drugs are designed to promote secretion clearance and to specifically alter the viscoelastic properties of mucus, restoring an effective mucociliary clearance and reducing broncho-obstructive symptoms. In association with mucolytics, these patients frequently also receive antibiotics to reduce the bacterial load, thus decreasing the release of infectious and pro-inflammatory products. Erdosteine is one of the most used mucoactive agents for the treatment of several respiratory diseases where the overlap of bacterial infection is frequent. Although the effectiveness in the reducing mucus in acute and chronic respiratory disease has been demonstrated for others mucolytic, some of them when given in combination with an antibiotic therapy, could reduce the antibiotic efficacy in some situation. Differently, erdosteine potentiates the antibiotic effect when given in combination with antibiotics. We have reviewed the literature available on both clinical and in vitro studies that have investigated this effect of erdosteine on t...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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AbstractIntroductionRisk of osteoporosis known to increase in chronic obstructive pulmonary disease (COPD), but is usually overlooked, especially in male patients.ObjectivesThe present study compares the bone mineral density (BMD) measurements of male COPD patients with emphysema and the chronic bronchitis phenotype, and evaluates the association between density of emphysema and osteoporosis.MethodsNinety ‐four patients with COPD, and with emphysema and the chronic bronchitis phenotype, were included in the prospective study. A high‐resolution computed tomography (HRCT) was used for the diagnosis of emphysema, and a du...
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
This study reveals that chronic CS exposure modulates the expression of various PDE members. Thus, CS exposure may change the levels of intracellular cyclic nucleotides and thereby impact the efficiency of PDE-targeted therapies. PMID: 31664853 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - Category: Cytology Authors: Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
ConclusionEvery section of the N 131 report showed significant inconsistencies among the summary survey results for both the Irkutsk Region and Russia. This could result in a misunderstanding of disease prevalence and, consequently, in improper decision making. At this point, approaches to statistical analysis of health surveys must be reconsidered on a national scale.
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
This study offers insight for understanding the effect of continuous exposure to SPF pollutants on endogenous antioxidant defenses in the airway epithelial and may be helpful in understanding human airway responses to swine barn exposures. PMID: 31632542 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Publication date: Available online 21 October 2019Source: International Journal of PharmaceuticsAuthor(s): Sie Huey Lee, Desmond Heng, Jeanette W.P. Teo, Frederick K.Y. Toh, Reginald B.H. TanAbstractIn respiratory and genetic disorders such as asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis and cystic fibrosis (CF), the lungs produce excess mucus, resulting in a thickened mass, which clogs up the airways and reduces airflow. Consequently, breathing becomes more difficult. Medications that break down the structure of mucus will be especially useful in managing the early symptoms of these diseases an...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
In Reply We disagree with Drs Miller and Stanojevic that our results were mainly due to clinicians ’ use of the fixed ratio of 0.70 for the diagnosis of COPD. Clinicians were blinded to study spirometry, and spirometry is substantially underutilized in clinical care. Furthermore, in the context of substantial debate on optimal spirometric criteria, it is unknown which threshold may have been se lected by treating physicians. In a number of cases, it is possible that a clinical diagnosis of chronic bronchitis was made. A diagnostic threshold should have meaningful prognostic utility, and in the absence of a diagnostic...
Source: JAMA - Category: General Medicine Source Type: research
ConclusionAccording to this study increasing the NO2 concentration has a direct and a significant effect on chronic obstructive pulmonary diseases. Electrical heating, alternative fuels solar and cooking are important factors in decreasing the concentration of NO2.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
AbstractIntroductionRisk of osteoporosis known to increase in COPD, but is usually overlooked, especially in male patients.ObjectivesThe present study compares the bone mineral density (BMD) measurements of male COPD patients with emphysema and the chronic bronchitis phenotype, and evaluates the association between density of emphysema and osteoporosis.Methods94 patients with COPD, and with emphysema and the chronic bronchitis phenotype were included in the prospective study. A high resolution computed tomography (HRCT) was used for the diagnosis of emphysema, dual X ‐ray absorptiometry was used to measure the BMD of the...
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
We thank M. Miravitlles and colleagues for their interest in our work [1]. They express concern about our failure rate: 24% at 10 days, and 45% at day 30; they feel that 31% of patients of the C-reactive protein (CRP) group and 46% of patients of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy group treated with antibiotics for acute COPD exacerbation is low in this high-risk population of hospitalised patients. Although treatment failure is high in our study, it reflects the severity of our population. Indeed, the proportion of patients on antimicrobials is lower than the outpatient study p...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Correspondence Source Type: research
This study aimed to evaluate the content that is available on COPD-related Facebook Groups, as well as the communication (self-disclosures, social support) and engagement (agreement, emotional reaction) strategies used by members to facilitate these resources. Two researchers independently searched the “Groups” category using the terms “COPD”, “emphysema”, and “chronic bronchitis”. Twenty-six closed (n = 23) and public (n = 3) COPD Facebook Groups were identified with 87,082 total members. The vast majority of Group members belonged to closed (...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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