High Throughput Screening (HTS) to Discover Chemical Probes (R01)

Technological innovations in high throughput screening (HTS), chemical synthesis, and cheminformatics have allowed rapid discovery of novel, small-molecule probes for the study of disease related biological processes and mechanisms in academic environments (see Academic Screening Facilities Directory, http://www.slas.org/screeningFacilities/facilityList.cfm). This provides an unprecedented opportunity for investigators to translate knowledge about diseases into tangible tools for translational research. This Funding Opportunity Announcement (FOA) aims to support investigators to form collaborations with an academic, nonprofit, or commercial HTS screening facility that has the requisite expertise and experience to implement an HTS-ready assay for the discovery and development of small molecule chemical probes. Through this FOA, NIH wishes to stimulate research in 1) discovery and development of novel, small molecules for their potential use in studying disease treatments relevant to the missions of the participating NIH Institutes, and 2) discovery and/or validation of novel, biological targets that will inform studies of disease mechanisms. Emphasis will be placed on projects that provide new insight into important disease targets and processes. For example, applications may involve emerging therapeutic targets and mechanisms for the discovery of chemical probes that may lead to further development of therapeutics or provide insight into the biology of relevant diseases and h...
Source: NINDS Funding Announcements: National Institute of Neurological Disorders and Stroke - Category: Neurology Source Type: funding

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Study Design. Retrospective cohort study. Objective. Compare a novel two-step algorithm for indicating a computed tomography angiography (CTA) in the setting of a cervical spine fracture with established gold standard criteria. Summary of Background Data. As CTA permits the rapid detection of blunt cerebrovascular injuries (BCVI), screening criteria for its use have broadened. However, more recent work warns of the potential for the overdiagnosis of BCVI, which must be considered with the adoption of broad criteria. Methods. A novel two-step metric for indicating CTA screening was compared with the American Coll...
Source: Spine - Category: Orthopaedics Tags: DIAGNOSTICS Source Type: research
This study aimed to provide more insight on the influence of sex on EVT outcome.Stroke
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news
This article explores the relationship between AF and HF and the thromboembolic effect of these diseases. Morbidity and mortality are increased when the 2 conditions are seen together. Stroke risks are significant with AF and all subtypes of HF. This article suggests that all patients with AF and HF should be considered for anticoagulation. Current evidence suggests that non –vitamin K antagonist oral anticoagulants are effective and safe in AF and HF in comparison with warfarin.
Source: Heart Failure Clinics - Category: Cardiology Authors: Source Type: research
Publication date: Available online 13 November 2019Source: Journal of Neuroscience MethodsAuthor(s): Brittanie Partridge, John H. RossmeislAbstractClinical translation of novel therapeutics that improve the survival and quality of life of patients with neurological disease remains a challenge, with many investigational drug and device candidates failing in advanced stage clinical trials. Naturally occurring inherited and acquired neurological diseases, such as epilepsy, inborn errors of metabolism, brain tumors, spinal cord injury, and stroke occur frequently in companion animals, and many of these share epidemiologic, pat...
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
Benbir Senel G, Karadeniz D. Every patient with acute ischemic stroke should be screened for sleep-disordered breathing.J Clin Sleep Med. 2019;15(11):1705–1706.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
DISCUSSION: CMDs, especially when comorbid, are associated with increased dementia risk; however, leisure activities and social integration mitigate this risk. PMID: 31718906 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Publication date: Available online 13 November 2019Source: Microvascular ResearchAuthor(s): Sandra Bonfante, Amanda Della Giustina, Lucineia Gainski Danielski, Tais Denicol, Larissa Joaquim, Erica Biehl, Gabriel Scopel, Raquel Jaconi de Carli, Marcos Hubner, Taise Cardoso, Talita Tuon, Jaqueline Generoso, Tatiana Barichello, Silvia Terra, Fabricia PetronilhoAbstractBlood brain barrier (BBB) permeability and oxidative stress have been reported to be important mechanisms for brain damage following ischemic stroke and stanniocalcin-1 (STC-1), a neuroprotective protein, has anti-inflammatory and anti-oxidative stress propertie...
Source: Microvascular Research - Category: Biochemistry Source Type: research
A panel of experts to the U.S. FDA recommended allowing Amarin Corp Plc's fish-oil derived drug to be used as an add-on therapy for reducing the chance of heart attacks and strokes in high-risk patients with cardiovascular disease.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Dear Candid Caregiver: I’m a divorced, middle-aged woman who’d very much enjoy a relationship but I can’t even date because my mother gets mad when I do. I thought that I’d left this behind after high school but I’m obviously wrong. Mom had a stroke two years ago and recovered as well as can be expected. Other than having a slight limp, there’s little physical sign of what she went through. The problem is that six months after her stroke, she was diagnosed with a combination of vascular dementia and Alzheimer’s dementia. I moved her in with me so that I could provide care when...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
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