Targeting Upstream Kinases of STAT3 in Human Medulloblastoma cells.

CONCLUSION: Our results suggest that the small molecule inhibitors of STAT3 upstream kinases, ruxolitinib, tofactinib, KX2-391, and dasatinib could be novel and attractive candidate drugs for the treatments of human medulloblastoma. PMID: 30332965 [PubMed - as supplied by publisher]
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Authors: Tags: Curr Cancer Drug Targets Source Type: research

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Brain tumors are the most common solid cancer in children younger than 15 years old.[1] Radiation therapy (RT) remains integral to the treatment of pediatric brain tumors, having significantly improved disease prognosis for common malignant tumors such as medulloblastomas: in average-risk disease, the 5-year survival for these tumors is now at 70-80%.[2,3] Elevated 5-year survival rates have also been achieved through the use of RT as a stand-alone therapy in the treatment of germinomas.[4] Despite having contributed to the overall survival benefit experienced by patients, such therapeutic approaches are associated with lo...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Conclusions: Normal tissue sparing was achieved regardless of patient age for infratentorial tumours. However, for supratentorial tumours, there was a dosimetric advantage of IMPT across 9 vs. 13-year-old patients.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
CONCLUSIONS: Our results suggest that AsiDNA is an attractive candidate to improve radiation therapy in MB, with no indication of additional toxicity in developing brain tissues. PMID: 32900798 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
mino Valeria Pensotti Siranoush Manoukian Li-Fraumeni syndrome (LFS) is an autosomal dominant disorder caused by mutations in the TP53 gene, predisposing to a wide spectrum of early-onset cancers, including brain tumors. In medulloblastoma patients, the role of TP53 has been extensively investigated, though the prevalence of de novo mutations has not been addressed. We characterized TP53 mutations in a monocentric cohort of consecutive Sonic Hedgehog (SHH)-activated medulloblastoma patients. Germline testing was offered based on tumor p53 immunostaining positivity. Among 24 patients, three (12.5%) showed tumor p53 ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
mino Valeria Pensotti Siranoush Manoukian Li-Fraumeni syndrome (LFS) is an autosomal dominant disorder caused by mutations in the TP53 gene, predisposing to a wide spectrum of early-onset cancers, including brain tumors. In medulloblastoma patients, the role of TP53 has been extensively investigated, though the prevalence of de novo mutations has not been addressed. We characterized TP53 mutations in a monocentric cohort of consecutive Sonic Hedgehog (SHH)-activated medulloblastoma patients. Germline testing was offered based on tumor p53 immunostaining positivity. Among 24 patients, three (12.5%) showed tumor p53 ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conditions:   Anaplastic Ependymoma;   Atypical Teratoid/Rhabdoid Tumor;   Central Nervous System Germ Cell Tumor;   Choroid Plexus Carcinoma;   Intracranial Myeloid Sarcoma;   Malignant Brain Neoplasm;   Malignant Glioma;   Medulloblastoma;   Primitive Neuroectodermal Tumor;   Recur rent Anaplastic Ependymoma;   Recurrent Atypical Teratoid/Rhabdoid Tumor;   Recurrent Malignant Brain Neoplasm;   Recurrent Malignant Glioma; &nb...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Parkkila Carbonic anhydrases (CAs) are zinc-containing metalloenzymes that participate in the regulation of pH homeostasis in addition to many other important physiological functions. Importantly, CAs have been associated with neoplastic processes and cancer. Brain tumors represent a heterogeneous group of diseases with a frequently dismal prognosis, and new treatment options are urgently needed. In this review article, we summarize the previously published literature about CAs in brain tumors, especially on CA II and hypoxia-inducible CA IX and CA XII. We review here their role in tumorigenesis and potential value in ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
n Charles L. Limoli Major advances in high precision treatment delivery and imaging have greatly improved the tolerance of radiotherapy (RT); however, the selective sparing of normal tissue and the reduction of neurocognitive side effects from radiation-induced toxicities remain significant problems for pediatric patients with brain tumors. While the overall survival of pediatric patients afflicted with medulloblastoma (MB), the most common type primary brain cancer in children, remains high (≥80%), lifelong neurotoxic side-effects are commonplace and adversely impact patients’ quality of life. To ci...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionThe results obtained in our combined series are comparable with, or even better than those obtained after high CSI doses, underscoring the need to reconsider this treatment in adults.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
Authors: Koga T, Chen CC, Furnari FB Abstract Genome engineering using programmable nucleases such as transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeat-associated protein nine facilitated the introduction of genetic alterations at specific genomic sites in various cell types. These tools have been applied to cancer modeling to understand the pathogenic effects of the growing catalog of mutations found in human cancers. Pertaining to brain tumors, neural progenitor cells derived from human induced pluripotent stem cells (iPSCs) engineered with differ...
Source: Neurologia Medico-Chirurgica - Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
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