Targeting Upstream Kinases of STAT3 in Human Medulloblastoma cells.

CONCLUSION: Our results suggest that the small molecule inhibitors of STAT3 upstream kinases, ruxolitinib, tofactinib, KX2-391, and dasatinib could be novel and attractive candidate drugs for the treatments of human medulloblastoma. PMID: 30332965 [PubMed - as supplied by publisher]
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Authors: Tags: Curr Cancer Drug Targets Source Type: research

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Toni Ilsley's son Charlie, now 12, from Reading, was diagnosed with the brain tumour medulloblastoma when he was just eight years old in 2015. It spread to his spine last year.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The human neurotropic virus JCPyV, a member of the Polyomaviridiae family, is the opportunistic infectious agent of Progressive Multifocal Leukoencephalopathy (PML), a fatal disease seen in severe immunosuppressive conditions and, during the last decade, in patients undergoing immunotherapy. JCPyV is a ubiquitous pathogen with up to 85% of the adult population word-wide exhibiting antibodies against it. Early experiments demonstrated that direct inoculation of JCPyV into the brain of different species resulted in the development of brain tumors and other neuroectodermal-derived neoplasias. Later, several reports showed the...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: CD133 is a marker for medulloblastoma SCLCCs. Both CD133-enriched and CD133-depleted medulloblastoma cell populations demonstrated sensitivity to UAB30, indicating its potential as a therapeutic option for group 3 medulloblastoma. PMID: 31362265 [PubMed - as supplied by publisher]
Source: Translational Oncology - Category: Cancer & Oncology Authors: Tags: Transl Oncol Source Type: research
(St. Jude Children's Research Hospital) Investigators at St. Jude Children's Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric brain tumor. The work also has implications for how medulloblastoma is classified, which may eventually shape clinical care. The work appears as an advance online publication today in Nature.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Conditions:   Brain Tumor;   Brain Tumor, Recurrent;   Brain Tumor, Refractory;   Brain Tumor, Pediatric;   Medulloblastoma;   Medulloblastoma Recurrent;   Medulloblastoma, Non-WNT/Non-SHH;   Medulloblastoma, Non-WNT/Non-SHH, Group 3;   Medulloblastoma, Non-WNT/Non-SHH, Group 4;   Brai n Cancer;   CNS Cancer;   CNS Tumor;   CNS Neoplasm Interventions:   Drug: Prexasertib;   Drug: Cyclophosphamide;   Drug: Gemcitabine;   Biological:...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Mojgan Rastegar Medulloblastoma is a common pediatric brain tumor and one of the main types of solid cancers in children below the age of 10. Recently, cholesterol-lowering “statin” drugs have been highlighted for their possible anti-cancer effects. Clinically, statins are reported to have promising potential for consideration as an adjuvant therapy in different types of cancers. However, the anti-cancer effects of statins in medulloblastoma brain tumor cells are not currently well-defined. Here, we investigated the cell death mechanisms by which simvastatin mediates its effects on different human...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Neurotrophins are critically involved in regulating normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that acts by binding to the tropomyosin receptor kinase B (TrkB) receptor, has also been implicated in the progression of several types of cancer. However, its role in medulloblastoma (MB), the most common type of malignant brain tumor afflicting children, remains unclear. Here we show that selective TrkB inhibition with the small molecule compound ANA-12 impaired proliferation and viability of human UW228 and D283 MB cells, and slowed the growth of MB tumors xenografted int...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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