Inexpensive Weight-Reducing Aid (L-Carnitine) as An Efficient Catalyst for Synthesis of Benzimidazoles.

CONCLUSION: A facile synthesis of benzimidazoles comprising the reaction of various aldehydes with substituted o-phenylendiamine in good to excellent yield is provided using L-Carnitine as an efficient catalyst. The protocol overcomes the earlier disadvantages like harsh reaction conditions, tedious work-up, expensive process, wastes generation and the use of metallic oxide, which might be applied to synthesis of benzimidazoles pharmaceticals in order to meet friendly environmental demands.
PMID: 30338731 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - October 18, 2018 Category: Chemistry Authors: Zhang M, Huang G, Zhang X, Lin Z, Li Y, Li B, Chen L Tags: Comb Chem High Throughput Screen Source Type: research