Evaluation of the Insulin-like Growth Factor Receptor Pathway in Patients with Advanced Breast Cancer Treated with Trastuzumab

Conclusion: This study revealed a crosstalk between the IGF-R pathway and HER2. There was evidence that high Akt1 and GLP-1R mRNA expression might affect survival among HER2-positive metastatic breast cancer patients treated with trastuzumab.

Source: Cancer Genomics and Proteomics - October 20, 2018 Category: Cancer & Oncology Authors: CHRISTODOULOU, C., OIKONOMOPOULOS, G., KOLIOU, G. A., KOSTOPOULOS, I., KOTOULA, V., BOBOS, M., PENTHEROUDAKIS, G., LAZARIDIS, G., SKONDRA, M., CHRISAFI, S., KOUTRAS, A., BAFALOUKOS, D., RAZIS, E., PAPADOPOULOU, K., PAPAKOSTAS, P., KALOFONOS, H. P., PECTAS Tags: Article Source Type: research