PLGA-amoxicillin-loaded layer formed on anodized Ti alloy as a hybrid material for dental implant applications

Publication date: 1 January 2019Source: Materials Science and Engineering: C, Volume 94Author(s): Alicja Kazek-Kęsik, Agnieszka Nosol, Joanna Płonka, Monika Śmiga-Matuszowicz, Monika Gołda-Cępa, Małgorzata Krok-Borkowicz, Monika Brzychczy-Włoch, Elżbieta Pamuła, Wojciech SimkaAbstractIn this paper, the preparation of a functional hybrid coating loaded with a drug (amoxicillin) on a promising titanium alloy – Ti-15Mo alloy is presented. The titanium alloy surface was anodized in solution with bioactive compounds to obtain a porous oxide layer favorable for MG-63 osteoblast-like cell adhesion. Then, a poly(lactide-co-glycolide) (PLGA) loaded with amoxicillin layer was formed using a dip-coating technique to cover the oxide layer, without filling in all of the pores. The morphology of the surface was evaluated using scanning electron microscopy supported by 3D Roughness Reconstruction software. The surface treatment of the Ti-15Mo alloy surface caused the surface roughness to increase up to 1.71 μm. The anodization process caused the Ti-15Mo alloy surface to become slightly more hydrophilic; however, the formation of the PLGA layer loaded with drug increased the contact angle to 96.5° ± 2.2°, respectively. After 4 weeks of polymer layer degradation, the registered signals on the 1H NMR spectrum were identical to the signals registered for lactic acid (LAc), which confirms that the polymer layer was degraded within a short period of time. The concentration ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research