Ameliorative Effect of Dietary Supplementation of Copper Oxide Nanoparticles on Inflammatory and Immune Reponses in Commercial Broiler under Normal and Heat-Stress Housing Conditions

Publication date: Available online 19 October 2018Source: Journal of Thermal BiologyAuthor(s): Seham El-Kassas, Safaa E. Abdo, Karima El-Naggar, Walied Abdo, Abeer A.K. Kirrella, Toufic O NasharAbstractHeat stress (HS) is one of the most serious adverse conditions that affect poultry causing immunosuppression and decreasing production. In a novel approach, we investigated effects of supplementing copper oxide nanoparticles (CuO-NPs) on the immune response in two commercial broiler strains (Ross 308 and Cobb 500). At one day old, birds were divided into 3 groups with 3 replicates for each. The first group received diet supplemented with 100% of their recommended copper requirements as CuO while, in the second and third groups, birds were given diets supplemented with 100 and 50% of the recommended Cu requirements in the form of CuO-NPs, respectively. At age of 21 day, each group was subdivided randomly into normal (24 ± 2 °C) and heat stressed (33 ± 2 °C for 5 h per day for two successive weeks) groups. Under normal housing temperature, CuO-NPs, significantly enhanced the immune response in these birds, compared to CuO shown by the increased levels of phagocytic activity (PA), lysozyme serum activity, and by upregulating immune-modulator genes including NF-κβ, PGES, IL-1β, TGF-1β, IFN-γ, BAX and CASP8. The responses were different between the two studied strains especially at the level of gene expression. In HS birds, supplementation of CuO-NPs reduced ...
Source: Journal of Thermal Biology - Category: Biology Source Type: research