Prothrombin complex concentrate versus placebo, no intervention, or other interventions in critically bleeding patients associated with oral anticoagulant administration: a protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

DiscussionAs critical bleeding in patients treated with oral anticoagulants is an increasing problem, an up-to-date systematic review evaluating the benefits and harms of prothrombin complex concentrate is urgently needed. It is the hope that this review will be able to guide best practice in treatment and clinical research of these critically bleeding patients.Systematic review registrationPROSPERO CRD42018084371
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research

Related Links:

Segmental arterial mediolysis (SAM) is a poorly understood, nonatherosclerotic, noninflammatory disease resulting from arterial medial degeneration. Patients may present with aneurysm, dissection, stenosis, or bleeding from visceral or renal arteries. Treatment algorithms are poorly characterized.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Clinical research study Source Type: research
Flatfoot surgery is evolving. As in other areas, less invasive techniques result in fewer wound complications, less postoperative pain, less bleeding, shorter hospital stays, and potentially shorter recovery times. In this article, we outline how the arthroscope can be used in flatfoot surgery to reduce the invasiveness of surgery. The article outlines how to perform a percutaneous gastrocnemius slide for the associated tight heel cord, and how to perform tibialis posterior tendoscopy. A percutaneous medializing calcaneal osteotomy can be performed as an arthroscopic guided procedure to confirm the placement of the saw, an...
Source: Techniques in Foot and Ankle Surgery - Category: Orthopaedics Tags: Special Focus: Adult Acquired Flatfoot Deformity (AAFD): To the Infinity and Beyond! Source Type: research
Publication date: Available online 21 November 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Riitta M. Antila, Johanna U. Mäenpää, Heini S. Huhtala, Eija I. Tomás, Synnöve M. StaffAbstractObjectiveTo evaluate the relationship between cesarean scar defect and abnormal uterine bleeding at one year after cesarean section (CS).Study DesignA prospective observational cohort study was conducted in 401 women who delivered by CS between January 2016 and January 2017. Women were screened for isthmocele with sonohysterography six months after CS and followed ...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Conclusion: The MIVA transcervical approach was technically feasible and reliable, with less invasiveness for PTC patients with PPLN metastases. Future studies are needed to accumulate more experience, investigate the indications of the technique, and determine the long-term oncological safety.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: Both methods were effective for the treatment of displaced clavicular mid-shaft fractures. However, the MIPO method might be better for recovery of shoulder and upper extremity function in the short term and might have a lower nonunion rate. PMID: 31746443 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Orthopadie und Unfallchirurgie - Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research
Authors: Xu J, Song Y, Gao Z, Jiang P, Liu R, Wang H, Qiao S, Gao R, Yang Y, Xu B, Yuan J Abstract To date, DAPT duration of 1 year is the standard treatment for ACS patients after DES implantation in China. However, less is known about the effect of prolonging DAPT duration of long-term outcome for this kind of patient in the real world of China. We carried out a large sample case in the biggest cardiovascular center in China to observe the effect of prolonging DAPT duration for more than 1 year on long-term outcome in ACS patients after PCI. We enrolled 5187 consecutive patients with ACS who underwent DES implant...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
Conditions:   Leiomyoma;   Pelvic Organ Prolapse;   Abnormal Uterine Bleeding;   Chronic Pain;   Premalignant Lesion;   Endometriosis Interventions:   Drug: Systemic multimodal analgesia administered intravenously;   Procedure: Transversus abdominis plane block (TAP block);   Other: Combined transversus abdominis plane block (TAP block) with systemic multimodal analgesia administered intravenously Sponsors:   General Hospital Pula;   Clinical Hospital Center Rijeka Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, sodium alginate (SA) was investigated for the first time as an auxiliary material in a polycarboxylate superplasticizer (PCE) system, and its interaction mechanism in a PCE-cement system was investigated, which is desirable to enhance the dispersion retention and solve the bleeding and segregation of fresh cement paste. Through the investigate of the adsorption and interaction of SA in cement or cement PCE system, the mechanism of SA improving the dispersion and other properties of cement paste was obtained. Results detailed from rheological measurements revealed that SA exhibits water retention and dispersi...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
CONCLUSIONS Early detection of SB CD without complications remains difficult even if advanced modalities are introduced. Our hypothesis is that the fecal occult blood test and routine blood test should be administered to patients with abdominal pain or gastrointestinal manifestations. Once the patients are found to have GI bleeding or anemia, they would be further examined according to the guideline and SBCE would be used in the early stage of SB CD. PMID: 31738744 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
On 13 November 2019, the Venezuela International Health Regulations (IHR) National Focal Point (NFP) and the Venezuela PAHO/WHO Country Office shared information about a confirmed case of yellow fever in Bolivar State. The case-patient is a 46-year-old male resident of the municipality of Gran Sabana, Bolivar State. He was in the locality of Uriman municipality of Gran Sabana within the 19 days prior to the onset of symptoms. Symptom onset was on 14 September 2019, and included fever, chills, nausea, vomiting, epistaxis, petechiae, and diarrhoea. On 26 September 2019, he visited a public hospital in the municipality of Her...
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
More News: Bleeding | Clinical Trials | Databases & Libraries | International Medicine & Public Health | Science | Study | Vitamin K | Vitamins