Stem Cells, Genome Editing, and the Path to Translational Medicine

Publication date: 18 October 2018Source: Cell, Volume 175, Issue 3Author(s): Frank Soldner, Rudolf JaenischThe derivation of human embryonic stem cells (hESCs) and the stunning discovery that somatic cells can be reprogrammed into human induced pluripotent stem cells (hiPSCs) holds the promise to revolutionize biomedical research and regenerative medicine. In this Review, we focus on disorders of the central nervous system and explore how advances in human pluripotent stem cells (hPSCs) coincide with evolutions in genome engineering and genomic technologies to provide realistic opportunities to tackle some of the most devastating complex disorders.
Source: Cell - Category: Cytology Source Type: research