Efficacy and safety of teriflunomide in Asian patients with relapsing forms of multiple sclerosis: A subgroup analysis of the phase 3 TOWER study

Publication date: Available online 20 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Aaron E. Miller, Xianhao Xu, Richard Macdonell, Steve Vucic, Philippe Truffinet, Myriam Benamor, Karthinathan Thangavelu, Mark S. FreedmanAbstractIn the phase 3 TOWER (NCT00751881) study, teriflunomide 14 mg significantly reduced annualized relapse rate (ARR) and risk of 12-week confirmed disability worsening (12-w CDW) vs placebo in patients with relapsing forms of MS (RMS). The TOWER population included an appreciable proportion of Asian patients. Reductions in ARR and 12-w CDW associated with teriflunomide 14 mg were comparable between the Asian and overall populations, as were the rates for adverse events and serious adverse events, with no new or unexpected safety findings. These observations provide further evidence to support the clinical benefits and safety profile of teriflunomide in a broad range of patients with RMS.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research

Related Links:

Eszter T óth, Péter Faragó, András Király, Nikoletta Szabó, Dániel Veréb, Krisztián Kocsis, Bálint Kincses, Dániel Sandi, Krisztina Bencsik, László Vécsei, Zsigmond Tamás Kincses
Source: Frontiers in Neurology - Category: Neurology Source Type: research
For more than twenty years now, Richard Burt's research teams have been working on the treatment of autoimmunity through the destruction and recreation of the immune system. Autoimmunity is a malfunction in the self-tolerance of immune cells, leading them to attack patient tissues. The malfunction is entirely contained in the immune system, so if the immune system is destroyed and replaced, the autoimmunity stops. If the genesis of autoimmunity is happenstance, an unfortunate one-time accident, then this is a cure. But if autoimmunity has a trigger outside the immune system in a given patient, it will return after some per...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Publication date: Available online 21 January 2019Source: The Lancet NeurologyAuthor(s): Mitchell T Wallin, William J Culpepper, Emma Nichols, Zulfiqar A Bhutta, Tsegaye Tewelde Gebrehiwot, Simon I Hay, Ibrahim A Khalil, Kristopher J Krohn, Xiaofeng Liang, Mohsen Naghavi, Ali H Mokdad, Molly R Nixon, Robert C Reiner, Benn Sartorius, Mari Smith, Roman Topor-Madry, Andrea Werdecker, Theo Vos, Valery L. Feigin, Christopher J L MurraySummaryBackgroundMultiple sclerosis is the most common inflammatory neurological disease in young adults. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systemati...
Source: The Lancet Neurology - Category: Neurology Source Type: research
AbstractObjectiveMultiple sclerosis is a neurological disorder —may in some patients have impact on body image; this could contribute to neurological disability, psychological distress, and can reduce quality of life. This review has been conducted on studies investigating the representation of body image.MethodWe have researched PubMed and Web of Science databases and included screening references for studies and review articles about this topic. From the initial 316 publications, we included only 9 studies that met the search criteria.Result and conclusionThe results showed that this construct has been little empha...
Source: Neurological Sciences - Category: Neurology Source Type: research
Publication date: February 2019Source: The Lancet Neurology, Volume 18, Issue 2Author(s): Olga Ciccarelli, Jeffrey A Cohen, Stephen C Reingold, Brian G Weinshenker, Maria Pia Amato, Brenda Banwell, Frederik Barkhof, Bruce Bebo, Burkhard Becher, François Bethoux, Alexander Brandt, Wallace Brownlee, Peter Calabresi, Jeremy Chatway, Claudia Chien, Tanuja Chitnis, Olga Ciccarelli, Jeffrey Cohen, Giancarlo Comi, Jorge CorrealeSummarySpinal cord involvement is an important cause of disability in patients with multiple sclerosis or neuromyelitis optica spectrum disorders (NMOSDs). Multiple sclerosis and NMOSDs can be disti...
Source: The Lancet Neurology - Category: Neurology Source Type: research
ConclusionOur 4-week program reduced some aspects of fatigue and improved some aspects of quality of life in a small group of ambulatory and non-ambulatory individuals with MS. Good feasibility and significant positive changes from baseline warrant further exploratory work.Trial registrationName of the registry: The Impact of Exercise Training on Living Quality in Multiple Sclerosis. Registration: The study was registered atwww.clinicaltrial.gov on July 14, 2017. First participant enrollment: August 28, 2017. URL: 602-01/17-01-147; Trial registration ID: NTC03222596.
Source: Neurological Sciences - Category: Neurology Source Type: research
CONCLUSIONS: Data portrayed social isolation as complex and multi-factorial in its definitions, its causes, and its impact. Isolation is not just about being lonely or left on one's own, but represents a spiral of impacts. Physical deterioration can lead to reduced choice and control regarding access to, and interaction with others and society, affecting personal identity. Sometimes this leads to further self-isolation. Personalised psychosocial support, with improved ease of access, focused on helping people with severe multiple sclerosis regain a sense of self and their place in the world may ease social isolation. Impli...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
Multiple sclerosis is a chronic incapacitating disease of the central nervous system, it has been reported that the disturbance in the development and function of Treg subpopulations is associated with the disability status in the RRMS. Accordingly, in the current study, the objective was to specify nanocurcumin effects on Treg cells frequency, and function in patients with RRMS.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research
CONCLUSION: Relaxation training is proposed as a clinically effective treatment for anxiety and depression in people living with long-term neurological conditions, which could in turn lead to better functional outcomes of neurorehabilitation. The program investigated here has additional benefits of being delivered in people's own homes, which overcomes barriers to attending hospital, and is consistent with trends towards home as opposed to hospital care. This program may also be less costly to administer as it can be delivered as part of a stepped-care program by therapy assistants under supervision from qualified staff, a...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
(University of Melbourne) An international study finds multiple sclerosis treatments have long-term benefits, and that early treatment is important. The Royal Melbourne Hospital and University of Melbourne-led study is the first to provide evidence that the currently available therapies can delay progression of disability in Multiple Sclerosis. It showed that early treatment -- particularly within five years of onset -- delayed the secondary progressive stage of MS, which is characterised by an ongoing increase of disability.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
More News: Brain | Disability | Multiple Sclerosis | Neurology | Neuroscience | Study