Contribution of the plasma and lymph Degradome and Peptidome to the MHC Ligandome

AbstractEvery biological fluid, blood, interstitial fluid and lymph, urine, saliva, lacrimal fluid, nipple aspirate, and spinal fluid, contains a peptidome-degradome derived from the cellular secretome along with byproducts of the metabolic/catabolic activities of each parenchymal organ. Clement et al. (J Proteomics 78:172 –187,2013), Clement et al. (J Biol Chem 291:5576 –5595,2016), Clement et al. (PLoS One 5:e9863,2010), Clement et al. (Trends Immunol 32:6 –11,2011), Clement et al. (Front Immunol 4:424,2013), Geho et al. (Curr Opin Chem Biol 10, 50 –55,2006), Interewicz et al. (Lymphology 37:65 ‑72,2004), Leak et al. (Proteomics 4:753 ‑765,2004), Popova et al. (PLoS One 9:e110873,2014), Zhou et al. (Electrophoresis 25:1289 ‑1298,2004), D'Alessandro et al. (Shock 42:509 ‑517,2014), Dzieciatkowska et al. (Shock 42:485 ‑498,2014), Dzieciatkowska et al. (Shock 35:331 ‑338,2011), Jordan et al. (J Surg Res 143:130 ‑135,2007), Peltz et al. (Surgery 146:347 ‑357,2009), Zurawel et al. (Clin Proteomics 8:1,2011), Ling et al. (Clin Proteomics 6:175 ‑193,2010), Sturm et al. (Nat Commun 4:1616,2013). Over the last decade, qualitative and quantitative analysis of the biological fluids peptidome and degradome have provided a dynamic measurement of tissue homeostasis as well as the tissue response to pathological damage. Proteomic profiling has mapped several of the proteases and resulting degradation by-products derived from cell cycle progression, organ/tissue r...
Source: Immunogenetics - Category: Genetics & Stem Cells Source Type: research