Chloroquine attenuates TLR3-mediated plasminogen activator inhibitor-1 expression in cultured human glomerular endothelial cells

ConclusionConsidering that TLR3 signaling is implicated in LN pathogenesis, our results suggest that chloroquine exert postulated renoprotective effects by inhibiting PAI-1 expression.

Source: Clinical and Experimental Nephrology - October 20, 2018 Category: Urology & Nephrology Source Type: research