GCN5 inhibition prevents IL-6-induced prostate cancer metastases by inactivating Egr-1.

In conclusion, these data demonstrated the negative effect of upregulated GCN5 in IL-6-induced metastasis and EMT in PCa cells through PI3K/PTEN/Akt sigaling pathway down-regulating Egr-1 expression.
PMID: 30333255 [PubMed - as supplied by publisher]

Source: Bioscience Reports - October 17, 2018 Category: Biomedical Science Authors: Shao G, Liu Y, Ma T, Zhang L, Yuan M, Zhao S Tags: Biosci Rep Source Type: research