Apoliporotein L3 interferes with endothelial tube formation via regulation of ERK1/2, FAK and Akt signaling pathway

Endothelial cells are main actors in vascular homeostasis as they regulate vascular pressure and permeability as well as hemostasis and inflammation. Disturbed stimuli delivered to and by endothelial cells correlate with the so-called endothelial dysfunction and disrupt this homeostasis. As constituents of the inner layer of blood vessels, endothelial cells are also involved in angiogenesis. Apolipoprotein Ls (APOL) comprise a family of newly discovered apolipoproteins with yet poorly understood function, and suggested to be involved in inflammatory processes and cell death mechanisms.

Source: Atherosclerosis - October 19, 2018 Category: Cardiology Authors: Alia Khalil, Philippe Poelvoorde, Mohammad Fayyad-Kazan, Alexandre Rousseau, Vincent Nuyens, Sophie Uzureau, Patrick Biston, EL-Makhour Yolla, Bassam Badran, Pierre Van Antwerpen, Karim Zouaoui Boudjeltia, Luc Vanhamme Source Type: research