Pulmonary follicular lymphoma showing diffuse micronodules mimicking sarcoidosis.

Pulmonary follicular lymphoma showing diffuse micronodules mimicking sarcoidosis. Intern Med. 2018 Oct 17;: Authors: Takuma K, Eri H, Satoshi I, Takashi O PMID: 30333400 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research

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Granulomatous myopathy is a clinically and etiologically heterogeneous group of uncommon inflammatory myopathies, pathologically characterized by the presence of granulomas in skeletal muscle. Granulomas may contain necrosis as typically seen in infectious disorders (fungal, tuberculosis, or brucellosis) [1-3] or may occur without necrosis, so-called non-necrotizing or non-caseating granulomas. Various disorders were reported in association with non-caseating granulomatous myopathy, including sarcoidosis and less commonly other autoimmune diseases (Crohn's disease, anti-mitochondrial autoimmunity with or without primary bi...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
International Journal of Dermatology, EarlyView.
Source: International Journal of Dermatology - Category: Dermatology Authors: Tags: Correspondence Source Type: research
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of extranodal diffuse large B-cell lymphoma characterized by proliferation of B cells within small vessels. Herein, we report a case of a 77-year-...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Case report Source Type: research
Abstract Salivary gland (SG) biopsy is a technique broadly applied for the diagnosis of primary Sjögren's syndrome (pSS), lymphoma accompanying SS, sarcoidosis, amyloidosis, and IgG4-related disease The most peculiar feature of pSS on biopsy is focal lymphocytic sialadenitis. In the past, several histological scores have been reported in the literature to describe glandular involvement during pSS. However, the variability among centres in reporting glandular scores is one of the rationales behind the development of standardised consensus guidance. SGs as well as lacrimal glands are involved in up to 50% of pa...
Source: Reumatismo - Category: Rheumatology Authors: Tags: Reumatismo Source Type: research
Background: The 2016 CHEST consensus guidelines recommend use of either 21- or 22-G needles for endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). We decided to prospectively compare sample adequacy and diagnostic yield of the 19-G with the 22-G EBUS needle, hypothesizing that a larger gauge difference might magnify the differences between 2 needle sizes. Methods: Twenty-seven patients undergoing EBUS-TBNA at our institution were evaluated. All cases were performed by a single operator formally trained in interventional pulmonology. Both Olympus 19- and 22-G needles were used at each lymph n...
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
Conditions:   Neoplasms;   Infection;   Inflammation;   Lymphoma;   Cancer;   Sarcoid;   Mass Lesion Interventions:   Procedure: Standard suction, slow-pull, wet suction;   Procedure: Standard suction, wet suction, slow-pull;   Procedure: Slow-pull, standard suction, wet suction;   Procedure: Slow-pull, wet suction, standard suction;   Procedure: Wet suction, standard suction, slow-pull;   Procedure: Wet s uction, slow-pull, standard suction Sponsor:   Shanghai Zhongshan Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion EBUS-TBNA with a 19-G needle was useful for diagnosing retinal hemangioblastoma and tuberculous lymphadenitis as well as for PD-L1 testing after 21- and 22-G biopsies were unsuccessful. PMID: 30146572 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
AbstractA 40-year-old male was hospitalized with renal impairment and severe hypercalcemia. His concentration of serum IgG4 was high, but serum whole PTH, 1 –25(OH)2 vitamin D3 and PTHrP were not elevated. Computed tomography showed swelling of the bilateral lacrimal glands and systemic lymphadenopathy. The histological findings of lacrimal gland biopsy fulfilled the diagnostic criteria of IgG4-related ophthalmic disease (IgG4ROD). Bone scintigraphy showed increased ectopic uptake in the stomach, heart, lungs, and kidneys. He died on day 16 of admission, although the therapies for hypercalcemia were continued. Autops...
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
When the patient's autoimmune disorder didn't respond to treatment, an additional workup uncovered a malignancy; one with an undefined connection. A 73-year-old woman presented with fatigue, left upper quadrant pain, headache, nausea, and cognitive dysfunction. An initial workup revealed  hypercalcemia, a low level of parathyroid hormone, elevated levels of angiotensin converting enzyme and alkaline phosphatase, pancytopenia, and mediastinal lymphadenopathy (Table 1). While magnetic resonance imaging (MRI) of her brain produced unremarkable results, abdominal imaging showed tra ce ascites, mil...
Source: The American Journal of Medicine - Category: General Medicine Authors: Source Type: research
Introduction: Binding of programmed cell death 1 (PD-1) ligands to PD-1 receptors found on T cells, inhibits T-cell proliferation and contributes to immune tolerance and inhibition of tumor surveillance. Nivolumab is a monoclonal antibody that binds to PD-1 receptor and inhibits this pathway. Given its antitumor capabilities, this medication was recently approved in Canada and the U.S. for the treatment of unresectable or metastatic melanoma, metastatic nonsmall cell lung cancer, renal carcinoma, and classical Hodgkin lymphoma.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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